ENSMUSG00000020048


Mus musculus

Features
Gene ID: ENSMUSG00000020048
  
Biological name :Hsp90b1
  
Synonyms : heat shock protein 90, beta (Grp94), member 1 / Hsp90b1 / P08113
  
Possible biological names infered from orthology : heat shock protein 90 beta family member 1 / P14625
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 86690209
Gene end: 86705509
  
Corresponding Affymetrix probe sets: 10371482 (MoGene1.0st)   1415889_a_at (Mouse Genome 430 2.0 Array)   1438040_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020238
Ensembl peptide - ENSMUSP00000122710
NCBI entrez gene - 22027     See in Manteia.
MGI - MGI:98817
RefSeq - NM_011631
RefSeq Peptide - NP_035761
swissprot - F7C312
swissprot - P08113
swissprot - Q3UAD6
Ensembl - ENSMUSG00000020048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hsp90b1ENSDARG00000003570Danio rerio
 HSP90B1ENSGALG00000033789Gallus gallus
 P14625ENSG00000166598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*ENSMUSG0000002394442
P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*ENSMUSG0000002127041
Trap1 / Q9CQN1 / Heat shock protein 75 kDa, mitochondrial / Q12931* / TNF receptor associated protein 1*ENSMUSG0000000598126


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR019805  Heat shock protein Hsp90, conserved site
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037196  HSP90, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IEA
 biological_processGO:0031247 actin rod assembly ISO
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity ISO
 biological_processGO:0071318 cellular response to ATP ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005788 endoplasmic reticulum lumen ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0034663 endoplasmic reticulum chaperone complex IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Scavenging by Class A Receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001674 abnormal triploblastic development "abnormal development of the three primary germ layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0001685 abnormal endoderm development "failure or abnormality in the formation of the endoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsp90b1tm1Zhli/Hsp90b1tm1.1Zhli,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv

 MP:0003890 abnormal embryonic-extraembryonic boundary morphology "anomaly in the normal development /maintenance of the connection between the embryo proper and extraembryonic tissues" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0009593 absent chorion "absence of the outermost extraembryonic membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Hsp90b1tm1.2Alee/Hsp90b1tm1.2Alee
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Ighg1tm2Cgn/Ighg1+
Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023973 3 / Cnpy3 / Q9DAU1 / Q9BT09* / canopy FGF signaling regulator 3*  / reaction / complex
 ENSMUSG00000020048 P08113 / Hsp90b1 / heat shock protein 90, beta (Grp94), member 1 / P14625* / heat shock protein 90 beta family member 1*  / complex
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / reaction / complex
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction / complex






 

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