ENSMUSG00000005981


Mus musculus

Features
Gene ID: ENSMUSG00000005981
  
Biological name :Trap1
  
Synonyms : Heat shock protein 75 kDa, mitochondrial / Q9CQN1 / Trap1
  
Possible biological names infered from orthology : Q12931 / TNF receptor associated protein 1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 4039971
Gene end: 4077827
  
Corresponding Affymetrix probe sets: 10437311 (MoGene1.0st)   1416170_at (Mouse Genome 430 2.0 Array)   1437379_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006137
Ensembl peptide - ENSMUSP00000138307
NCBI entrez gene - 68015     See in Manteia.
MGI - MGI:1915265
RefSeq - NM_026508
RefSeq Peptide - NP_080784
swissprot - Q9CQN1
swissprot - S4R1P4
Ensembl - ENSMUSG00000005981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trap1ENSDARG00000024317Danio rerio
 TRAP1ENSGALG00000039951Gallus gallus
 TRAP1ENSG00000126602Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P08113 / Hsp90b1 / heat shock protein 90, beta (Grp94), member 1 / P14625* / heat shock protein 90 beta family member 1*ENSMUSG0000002004830
P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*ENSMUSG0000002127029
P11499 / Hsp90ab1 / Heat shock protein HSP 90-beta / P08238* / heat shock protein 90 alpha family class B member 1*ENSMUSG0000002394429


Protein motifs (from Interpro)
Interpro ID Name
 IPR001404  Heat shock protein Hsp90 family
 IPR003594  Histidine kinase/HSP90-like ATPase
 IPR020568  Ribosomal protein S5 domain 2-type fold
 IPR020575  Heat shock protein Hsp90, N-terminal
 IPR036890  Histidine kinase/HSP90-like ATPase superfamily
 IPR037196  HSP90, C-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0009386 translational attenuation IEA
 biological_processGO:1901856 negative regulation of cellular respiration IEA
 biological_processGO:1903751 negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane ISO
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Disc1m1H/Disc1m1H
Genetic Background: B6N.C(C3H)-Disc1m1H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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