ENSMUSG00000045322


Mus musculus

Features
Gene ID: ENSMUSG00000045322
  
Biological name :Tlr9
  
Synonyms : Q9EQU3 / Tlr9 / Toll-like receptor 9
  
Possible biological names infered from orthology : AC097637.1 / Q9NR96
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 106222598
Gene end: 106226883
  
Corresponding Affymetrix probe sets: 10588479 (MoGene1.0st)   1422083_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082207
NCBI entrez gene - 81897     See in Manteia.
MGI - MGI:1932389
RefSeq - NM_031178
RefSeq Peptide - NP_112455
swissprot - Q9EQU3
Ensembl - ENSMUSG00000045322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr9ENSDARG00000044490Danio rerio
 AC097637.1ENSG00000173366Homo sapiens
 TLR9ENSG00000239732Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458336
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052234
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377722
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163921
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900518
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916418
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149817
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799517
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482715
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027181  Toll-like receptor 9
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0002218 activation of innate immune response IDA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0002237 response to molecule of bacterial origin TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002639 positive regulation of immunoglobulin production ISO
 biological_processGO:0002730 regulation of dendritic cell cytokine production IDA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IPI
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0007252 I-kappaB phosphorylation ISO
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0010508 positive regulation of autophagy IEA
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0030277 maintenance of gastrointestinal epithelium IMP
 biological_processGO:0030890 positive regulation of B cell proliferation ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032640 tumor necrosis factor production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032717 negative regulation of interleukin-8 production ISO
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production ISO
 biological_processGO:0032728 positive regulation of interferon-beta production IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032741 positive regulation of interleukin-18 production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway ISO
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway ISO
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IEA
 biological_processGO:0034163 regulation of toll-like receptor 9 signaling pathway ISO
 biological_processGO:0034165 positive regulation of toll-like receptor 9 signaling pathway IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0043410 positive regulation of MAPK cascade ISO
 biological_processGO:0043507 positive regulation of JUN kinase activity ISO
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process ISS
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process ISS
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process ISO
 biological_processGO:0045577 regulation of B cell differentiation ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium ISO
 biological_processGO:0050864 regulation of B cell activation IGI
 biological_processGO:0050871 positive regulation of B cell activation ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071248 cellular response to metal ion IEA
 biological_processGO:1901895 negative regulation of calcium-transporting ATPase activity ISO
 biological_processGO:1902350 cellular response to chloroquine IDA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome IDA
 cellular_componentGO:0036019 endolysosome IMP
 cellular_componentGO:0045335 phagocytic vesicle IGI
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035197 siRNA binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0045322 unmethylated CpG binding IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
Trafficking and processing of endosomal TLR
Toll Like Receptor 9 (TLR9) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Il4tm1Cgn/Il4tm1Cgn
Genetic Background: MRL.Cg-Il4tm1Cgn Faslpr

Allelic Composition: Tlr9tm1Aki/Tlr9tm1Aki,Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

Allelic Composition: Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selltm1Flv/Sell+
Genetic Background: involves: C57BL/6 * NOD

Allelic Composition: Tlr9M2Btlr/Tlr9M2Btlr
Genetic Background: C57BL/6J-Tlr9M2Btlr

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

Allelic Composition: Tlr9M1Btlr/Tlr9M1Btlr
Genetic Background: involves: C57BL/6

Allelic Composition: Tlr9M2Btlr/Tlr9M2Btlr
Genetic Background: C57BL/6J-Tlr9M2Btlr

Allelic Composition: Tlr9m3Btlr/Tlr9m3Btlr
Genetic Background: C57BL/6J-Tlr9m3Btlr

Allelic Composition: Tlr9M2Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M2Btlr

Allelic Composition: Tlr9m4Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9m4Btlr

Allelic Composition: Tlr9M5Btlr/?
Genetic Background: C57BL/6J-Tlr9M5Btlr

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr9M1Btlr/Tlr9M1Btlr
Genetic Background: involves: C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(Ccr2-GFP)8Pam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Tlr9tm1Aki/Tlr9tm1Aki,Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr9m3Btlr/Tlr9m3Btlr
Genetic Background: C57BL/6J-Tlr9m3Btlr

Allelic Composition: Tlr9m4Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9m4Btlr

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ddx4tm1Tnc/Ddx4+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NJcl

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Tlr9M1Btlr/Tlr9M1Btlr
Genetic Background: involves: C57BL/6

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Slc17a6tm1Lex/Slc17a6+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr9M5Btlr/?
Genetic Background: C57BL/6J-Tlr9M5Btlr

Allelic Composition: Tlr9M7Btlr/Tlr9M7Btlr
Genetic Background: C57BL/6J-Tlr9M7Btlr

Allelic Composition: Tlr9M7Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M7Btlr

Allelic Composition: Tlr9M9Btlr/Tlr9M9Btlr
Genetic Background: C57BL/6J-Tlr9M9Btlr

Allelic Composition: Tlr9M9Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M9Btlr

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr9M5Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M5Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

Allelic Composition: Tlr9M5Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9M5Btlr

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ucp2tm2.1Lowl/Ucp2tm2.1Lowl,Gt(ROSA)26Sortm1(CAG-Kcnj11*,-GFP)Nich/?,Tg(Pmch-cre)1Lowl/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/NJ

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: B6.129P2-Tlr2tm1Aki

 MP:0008769 abnormal plasmacytoid dendritic cell physiology "any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr9m4Btlr/Tlr9+
Genetic Background: C57BL/6J-Tlr9m4Btlr

Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: MRL.Cg-Tlr9tm1Aki Faslpr

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Tlr9M1Btlr/Tlr9M1Btlr
Genetic Background: involves: C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Faslpr/Faslpr,Tlr9tm1Aki/Tlr9tm1Aki
Genetic Background: B6.Cg-Tlr9tm1Aki Faslpr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038642 Ctss / O70370 / cathepsin S / P25774*  / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / reaction / complex
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / reaction / complex
 ENSMUSG00000020048 P08113 / Hsp90b1 / heat shock protein 90, beta (Grp94), member 1 / P14625* / heat shock protein 90 beta family member 1*  / complex / reaction
 ENSMUSG00000023973 3 / Cnpy3 / Q9DAU1 / Q9BT09* / canopy FGF signaling regulator 3*  / complex / reaction
 ENSMUSG00000036908 Unc93b1 / unc-93 homolog B1 (C. elegans) / Q9H1C4* / unc-93 homolog B1, TLR signaling regulator*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / reaction / complex
 ENSMUSG00000032571 Pik3r4 / Q8VD65 / Phosphoinositide 3-kinase regulatory subunit 4 / Q99570*  / reaction / complex
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000033628 Pik3c3 / Q6PF93 / Phosphatidylinositol 3-kinase catalytic subunit type 3 / Q8NEB9*  / reaction / complex






 

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