Manteia - Molecule gene

ENSMUSG00000036908

Mus musculus

Features

Gene ID:	ENSMUSG00000036908

Biological name :	Unc93b1

Synonyms :	Unc93b1 / unc-93 homolog B1 (C. elegans)

Possible biological names infered from orthology :	Q9H1C4 / unc-93 homolog B1, TLR signaling regulator

Species:	Mus musculus

Chr. number:	19
Strand:	1
Band:	A
Gene start:	3935186
Gene end:	3949340

Corresponding Affymetrix probe sets:	10460237 (MoGene1.0st) 1423768_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000124272 Ensembl peptide - ENSMUSP00000128751 NCBI entrez gene - 54445 See in Manteia. MGI - MGI:1859307 RefSeq - NM_019449 RefSeq - NM_001161428 RefSeq - XM_006531798 RefSeq Peptide - NP_001154900 RefSeq Peptide - NP_062322 swissprot - E9Q8P6 swissprot - E9PYK0 Ensembl - ENSMUSG00000036908

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
unc93b1	ENSDARG00000069114	Danio rerio
	ENSGALG00000039347	Gallus gallus
Q9H1C4	ENSG00000110057	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q710D3 / Unc93a / unc-93 homolog A (C. elegans) / Q86WB7* / unc-93 homolog A*	ENSMUSG00000067049	17
Gm9992 / Q86WB7* / UNC93A* / unc-93 homolog A*	ENSMUSG00000056133	17

Protein motifs (from Interpro)

Interpro ID	Name
IPR010291	Ion channel regulatory protein, UNC-93

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0034138	toll-like receptor 3 signaling pathway	IEA
biological_process	GO:0034154	toll-like receptor 7 signaling pathway	IEA
biological_process	GO:0034162	toll-like receptor 9 signaling pathway	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005783	endoplasmic reticulum	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA

Pathways (from Reactome)

Pathway description

Trafficking and processing of endosomal TLR

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0001655	multifocal hepatic necrosis	"multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0001836	abnormal antigen presentation via MHC class I	"anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr Allelic Composition: Tlr9^tm1Aki/Tlr9^tm1Aki,Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002376	abnormal dendritic cell physiology	"failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]	Show Allelic Composition: Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0002397	abnormal bone marrow morphology	"structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0002412	increased susceptibility to bacterial infection	"greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0002418	increased susceptibility to viral infection	"greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0002455	abnormal dendritic cell antigen presentation	"impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Unc93b1^3d/Unc93b1^3d Genetic Background: C57BL/6-Unc93b1^3d Allelic Composition: Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0002944	increased lactate dehydrogenase level	"greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0003009	abnormal cytokine secretion	"impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr Allelic Composition: Tlr9^tm1Aki/Tlr9^tm1Aki,Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ighm^tm1Cgn/Ighm^tm1Cgn,Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0003326	liver failure	"cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0003656	abnormal erythrocyte physiology	"functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0003725	increased autoantibody level	"elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0005041	abnormal antigen presentation via MHC class II	"anomaly in the process by which peptide, bound to major histocomptability complex class II, is presented to lymphocytes at the surface of antigen presenting cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0005093	impaired B cell proliferation	"absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0005343	increased circulating aspartate transaminase level	"greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0005461	abnormal dendritic cell morphology/development	"anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Unc93b1^3d/Unc93b1^3d Genetic Background: C57BL/6-Unc93b1^3d Allelic Composition: Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0005553	increased circulating creatinine level	"greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008049	increased memory T cell number	"greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008086	increased T-helper 1 cell number	"greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008088	abnormal T-helper 1 cell differentiation	"atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008182	decreased marginal zone B cell number	"reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008500	increased IgG2a level	"greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008501	increased IgG2b level	"greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008548	abnormal circulating interferon level	"anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0008556	abnormal tumor necrosis factor secretion	"anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008561	decreased tumor necrosis factor secretion	"reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008562	increased interferon-alpha secretion	"increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008563	decreased interferon-alpha secretion	"increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008597	decreased circulating interleukin-6 level	"reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0008648	decreased circulating interleukin-12b level	"reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]	Show Allelic Composition: Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0008669	increased interleukin-12b secretion	"increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]	Show Allelic Composition: Cdh23^v-bus/Cdh23^v-bus Genetic Background: involves: KYF/MsIdr
MP:0008670	decreased interleukin-12b secretion	"reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]	Show Allelic Composition: Kcnj11^tm1Sse/Kcnj11^tm1Sse Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Unc93b1^3d/Unc93b1^3d Genetic Background: C57BL/6-Unc93b1^3d Allelic Composition: Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Unc93b1^3d/Unc93b1^3d Genetic Background: C57BL/6-Unc93b1^3d
MP:0008752	abnormal tumor necrosis factor level	"deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]	Show Allelic Composition: Unc93b1^{tm1(KOMP)Vlcg}/Unc93b1^{tm1(KOMP)Vlcg} Genetic Background: involves: C57BL/6NTac
MP:0010219	increased T-helper 17 cell number	"increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]	Show Allelic Composition: Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010221	abnormal T-helper 17 cell differentiation	"atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]	Show Allelic Composition: Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010835	increased CD4-positive, alpha-beta memory T cell number	"increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]	Show Allelic Composition: Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011178	increased erythroblast number	"greater number of the nucleated precursor of erythrocytes" [MGI:csmith]	Show Allelic Composition: Unc93b1^tm1.1Kmiy/Unc93b1^tm1.1Kmiy Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031639	Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*	/ reaction / complex
ENSMUSG00000044583	Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*	/ complex / reaction
ENSMUSG00000045322	Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*	/ complex / reaction
ENSMUSG00000040522	Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*	/ reaction / complex

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr