ENSG00000110057


Homo sapiens

Features
Gene ID: ENSG00000110057
  
Biological name :UNC93B1
  
Synonyms : Q9H1C4 / UNC93B1 / unc-93 homolog B1, TLR signaling regulator
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.2
Gene start: 67991104
Gene end: 68004982
  
Corresponding Affymetrix probe sets: 220998_s_at (Human Genome U133 Plus 2.0 Array)   225869_s_at (Human Genome U133 Plus 2.0 Array)   227483_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000227471
Ensembl peptide - ENSP00000437195
Ensembl peptide - ENSP00000434294
NCBI entrez gene - 81622     See in Manteia.
OMIM - 608204
RefSeq - XM_011545290
RefSeq - XM_011545291
RefSeq - NM_030930
RefSeq Peptide - NP_112192
swissprot - Q9H1C4
swissprot - E9PR93
swissprot - E9PNE5
Ensembl - ENSG00000110057
  
Related genetic diseases (OMIM): 610551 - {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 1}, 610551
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc93b1ENSDARG00000069114Danio rerio
 ENSGALG00000039347Gallus gallus
 Unc93b1ENSMUSG00000036908Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q86WB7 / UNC93A / unc-93 homolog AENSG0000011249419


Protein motifs (from Interpro)
Interpro ID Name
 IPR010291  Ion channel regulatory protein, UNC-93


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006886 intracellular protein transport ISS
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034154 toll-like receptor 7 signaling pathway IMP
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome ISS
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0035325 Toll-like receptor binding IBA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
UNC93B1 deficiency - HSE


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101916 TLR8 / Q9NR97 / toll like receptor 8  / reaction / complex
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / reaction / complex
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / reaction / complex






 

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