ENSG00000239732


Homo sapiens

Features
Gene ID: ENSG00000239732
  
Biological name :TLR9
  
Synonyms : Q9NR96 / TLR9 / toll like receptor 9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p21.2
Gene start: 52221080
Gene end: 52226163
  
Corresponding Affymetrix probe sets: 223903_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000353874
NCBI entrez gene - 54106     See in Manteia.
OMIM - 605474
RefSeq - NM_017442
RefSeq Peptide - NP_059138
swissprot - Q9NR96
Ensembl - ENSG00000239732
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr9ENSDARG00000044490Danio rerio
 Tlr9ENSMUSG00000045322Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC097637.1ENSG00000173366100
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666435
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191634
TLR3 / O15455 / toll like receptor 3ENSG0000016434221
TLR4 / O00206 / toll like receptor 4ENSG0000013686918
TLR2 / O60603 / toll like receptor 2ENSG0000013746217
TLR5 / O60602 / toll like receptor 5ENSG0000018755417
CD180 / Q99467 / CD180 moleculeENSG0000013406116
TLR1 / Q15399 / toll like receptor 1ENSG0000017412515
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413015
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412315


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027181  Toll-like receptor 9
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002237 response to molecule of bacterial origin TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002639 positive regulation of immunoglobulin production IDA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IDA
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0030277 maintenance of gastrointestinal epithelium ISS
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032640 tumor necrosis factor production IDA
 biological_processGO:0032715 negative regulation of interleukin-6 production ISS
 biological_processGO:0032717 negative regulation of interleukin-8 production IDA
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production IDA
 biological_processGO:0032728 positive regulation of interferon-beta production ISS
 biological_processGO:0032733 positive regulation of interleukin-10 production ISS
 biological_processGO:0032735 positive regulation of interleukin-12 production ISS
 biological_processGO:0032741 positive regulation of interleukin-18 production ISS
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IDA
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway IDA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0034163 regulation of toll-like receptor 9 signaling pathway IDA
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0042742 defense response to bacterium NAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process IDA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IDA
 biological_processGO:0045577 regulation of B cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046330 positive regulation of JNK cascade IC
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050871 positive regulation of B cell activation IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS
 biological_processGO:1901895 negative regulation of calcium-transporting ATPase activity IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005576 extracellular region NAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome ISS
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0035197 siRNA binding IMP
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0045322 unmethylated CpG binding ISS


Pathways (from Reactome)
Pathway description
PI3K Cascade
Trafficking and processing of endosomal TLR
Toll Like Receptor 9 (TLR9) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110057 Q9H1C4 / UNC93B1 / unc-93 homolog B1, TLR signaling regulator  / reaction / complex
 ENSG00000078142 PIK3C3 / Q8NEB9 / phosphatidylinositol 3-kinase catalytic subunit type 3  / reaction / complex
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000166598 P14625 / HSP90B1 / heat shock protein 90 beta family member 1  / reaction / complex
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / complex / reaction
 ENSG00000196455 PIK3R4 / Q99570 / phosphoinositide-3-kinase regulatory subunit 4  / complex / reaction
 ENSG00000163131 CTSS / P25774 / cathepsin S  / reaction
 ENSG00000137161 CNPY3 / Q9BT09 / canopy FGF signaling regulator 3  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex






 

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