ENSG00000174123


Homo sapiens

Features
Gene ID: ENSG00000174123
  
Biological name :TLR10
  
Synonyms : Q9BXR5 / TLR10 / toll like receptor 10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p14
Gene start: 38772239
Gene end: 38782990
  
Corresponding Affymetrix probe sets: 223750_s_at (Human Genome U133 Plus 2.0 Array)   223751_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427606
Ensembl peptide - ENSP00000424923
Ensembl peptide - ENSP00000478206
Ensembl peptide - ENSP00000478985
Ensembl peptide - ENSP00000308925
Ensembl peptide - ENSP00000354459
Ensembl peptide - ENSP00000421483
NCBI entrez gene - 81793     See in Manteia.
OMIM - 606270
RefSeq - XM_011513762
RefSeq - NM_001017388
RefSeq - NM_001195106
RefSeq - NM_001195107
RefSeq - NM_001195108
RefSeq - NM_030956
RefSeq - XM_011513760
RefSeq - XM_011513761
RefSeq Peptide - NP_001017388
RefSeq Peptide - NP_001182037
RefSeq Peptide - NP_112218
RefSeq Peptide - NP_001182035
RefSeq Peptide - NP_001182036
swissprot - D6RHW6
swissprot - A0A024R9W4
swissprot - Q9BXR5
Ensembl - ENSG00000174123
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr1ENSDARG00000100649Danio rerio
 TLR1AENSGALG00000017485Gallus gallus
 TLR1BENSGALG00000027093Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR1 / Q15399 / toll like receptor 1ENSG0000017412548
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413046
TLR2 / O60603 / toll like receptor 2ENSG0000013746228
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191622
TLR4 / O00206 / toll like receptor 4ENSG0000013686921
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666420
TLR3 / O15455 / toll like receptor 3ENSG0000016434219
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973219
AC097637.1ENSG0000017336619
TLR5 / O60602 / toll like receptor 5ENSG0000018755418
CD180 / Q99467 / CD180 moleculeENSG0000013406112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027182  Toll-like receptor 10
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response NAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034166 toll-like receptor 10 signaling pathway TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 10 (TLR10) Cascade
IRAK4 deficiency (TLR5)
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex
 ENSG00000174123 TLR10 / Q9BXR5 / toll like receptor 10  / complex






 

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