ENSG00000174130


Homo sapiens

Features
Gene ID: ENSG00000174130
  
Biological name :TLR6
  
Synonyms : Q9Y2C9 / TLR6 / toll like receptor 6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p14
Gene start: 38823715
Gene end: 38856817
  
Corresponding Affymetrix probe sets: 207446_at (Human Genome U133 Plus 2.0 Array)   239021_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389600
Ensembl peptide - ENSP00000480266
Ensembl peptide - ENSP00000424718
Ensembl peptide - ENSP00000423326
Ensembl peptide - ENSP00000371376
NCBI entrez gene - 10333     See in Manteia.
OMIM - 605403
RefSeq - XM_011513613
RefSeq - XM_011513614
RefSeq - XM_011513612
RefSeq - NM_006068
RefSeq - XM_005262637
RefSeq Peptide - NP_006059
swissprot - Q9Y2C9
swissprot - D6R979
swissprot - D6RAV7
Ensembl - ENSG00000174130
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr1ENSDARG00000100649Danio rerio
 TLR1AENSGALG00000017485Gallus gallus
 TLR1BENSGALG00000027093Gallus gallus
 Tlr6ENSMUSG00000051498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR1 / Q15399 / toll like receptor 1ENSG0000017412568
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412347
TLR2 / O60603 / toll like receptor 2ENSG0000013746229
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191621
TLR4 / O00206 / toll like receptor 4ENSG0000013686921
TLR5 / O60602 / toll like receptor 5ENSG0000018755420
AC097637.1ENSG0000017336620
TLR3 / O15455 / toll like receptor 3ENSG0000016434220
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973220
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666419
CD180 / Q99467 / CD180 moleculeENSG0000013406112


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027187  Toll-like receptor 6
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001775 cell activation IDA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity NAS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0032493 response to bacterial lipoprotein IEA
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway IGI
 biological_processGO:0034150 toll-like receptor 6 signaling pathway IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway ISS
 biological_processGO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
 biological_processGO:0042088 T-helper 1 type immune response IEA
 biological_processGO:0042496 detection of diacyl bacterial lipopeptide IDA
 biological_processGO:0042742 defense response to bacterium TAS
 biological_processGO:0043032 positive regulation of macrophage activation ISS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043507 positive regulation of JUN kinase activity IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process ISS
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0046209 nitric oxide metabolic process IEA
 biological_processGO:0050702 interleukin-1 beta secretion ISS
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IGI
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IDA
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus ISS
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISS
 biological_processGO:1903223 positive regulation of oxidative stress-induced neuron death ISS
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process ISS
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 biological_processGO:2000483 negative regulation of interleukin-8 secretion IGI
 cellular_componentGO:0005622 intracellular IPI
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex IBA
 cellular_componentGO:0043235 receptor complex IPI
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IBA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035663 Toll-like receptor 2 binding IPI
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0071723 lipopeptide binding ISS


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000135218 CD36 / P16671 / CD36 molecule  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction






 

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