ENSG00000135218


Homo sapiens

Features
Gene ID: ENSG00000135218
  
Biological name :CD36
  
Synonyms : CD36 / CD36 molecule / P16671
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q21.11
Gene start: 80369575
Gene end: 80679277
  
Corresponding Affymetrix probe sets: 206488_s_at (Human Genome U133 Plus 2.0 Array)   209554_at (Human Genome U133 Plus 2.0 Array)   209555_s_at (Human Genome U133 Plus 2.0 Array)   228766_at (Human Genome U133 Plus 2.0 Array)   242197_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407690
Ensembl peptide - ENSP00000409762
Ensembl peptide - ENSP00000441956
Ensembl peptide - ENSP00000439543
Ensembl peptide - ENSP00000435698
Ensembl peptide - ENSP00000433659
Ensembl peptide - ENSP00000431296
Ensembl peptide - ENSP00000416388
Ensembl peptide - ENSP00000415743
Ensembl peptide - ENSP00000411411
Ensembl peptide - ENSP00000410371
Ensembl peptide - ENSP00000308165
Ensembl peptide - ENSP00000378268
Ensembl peptide - ENSP00000392298
Ensembl peptide - ENSP00000396258
Ensembl peptide - ENSP00000398760
Ensembl peptide - ENSP00000399421
Ensembl peptide - ENSP00000401863
NCBI entrez gene - 948     See in Manteia.
OMIM - 173510
RefSeq - XM_005250715
RefSeq - NM_000072
RefSeq - NM_001001547
RefSeq - NM_001001548
RefSeq - NM_001127443
RefSeq - NM_001127444
RefSeq - NM_001289908
RefSeq - NM_001289909
RefSeq - NM_001289911
RefSeq - XM_005250713
RefSeq - XM_005250714
RefSeq Peptide - NP_001120915
RefSeq Peptide - NP_001120916
RefSeq Peptide - NP_001276837
RefSeq Peptide - NP_001276838
RefSeq Peptide - NP_001276840
RefSeq Peptide - NP_000063
RefSeq Peptide - NP_001001547
RefSeq Peptide - NP_001001548
swissprot - H0YEE7
swissprot - E9PJX8
swissprot - E9PC45
swissprot - E7EX47
swissprot - E7EWI4
swissprot - E7EVU1
swissprot - E7EU05
swissprot - E7ERZ9
swissprot - P16671
swissprot - E9PLT1
swissprot - A4D1B1
Ensembl - ENSG00000135218
  
Related genetic diseases (OMIM): 173510 - [Macrothrombocytopenia]
  608404 - Platelet glycoprotein IV deficiency, 608404
  610938 - {Coronary heart disease, susceptibility to, 7}, 610938
  611162 - {Malaria, cerebral, reduced risk of}, 611162
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd36ENSDARG00000032639Danio rerio
 CD36ENSGALG00000008439Gallus gallus
 Cd36ENSMUSG00000002944Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q14108 / SCARB2 / scavenger receptor class B member 2ENSG0000013876032
Q8WTV0 / SCARB1 / scavenger receptor class B member 1ENSG0000007306032


Protein motifs (from Interpro)
Interpro ID Name
 IPR002159  CD36 family
 IPR005428  CD36/scavenger receptor class B member 1
 IPR033076  CD36


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001954 positive regulation of cell-matrix adhesion IDA
 biological_processGO:0002221 pattern recognition receptor signaling pathway IEA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006629 lipid metabolic process NAS
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0006910 phagocytosis, recognition IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007263 nitric oxide mediated signal transduction IDA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0010744 positive regulation of macrophage derived foam cell differentiation IMP
 biological_processGO:0010886 positive regulation of cholesterol storage IEA
 biological_processGO:0010942 positive regulation of cell death IMP
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0019934 cGMP-mediated signaling IDA
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0030299 intestinal cholesterol absorption ISS
 biological_processGO:0030301 cholesterol transport ISS
 biological_processGO:0031623 receptor internalization ISS
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033993 response to lipid ISS
 biological_processGO:0034121 regulation of toll-like receptor signaling pathway IGI
 biological_processGO:0034197 triglyceride transport ISS
 biological_processGO:0034381 plasma lipoprotein particle clearance ISS
 biological_processGO:0034383 low-density lipoprotein particle clearance IMP
 biological_processGO:0035634 response to stilbenoid IEA
 biological_processGO:0038124 toll-like receptor TLR6:TLR2 signaling pathway TAS
 biological_processGO:0042953 lipoprotein transport TAS
 biological_processGO:0042992 obsolete negative regulation of transcription factor import into nucleus IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0044539 long-chain fatty acid import IDA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process ISS
 biological_processGO:0050702 interleukin-1 beta secretion ISS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050892 intestinal absorption ISS
 biological_processGO:0050909 sensory perception of taste ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IGI
 biological_processGO:0055096 low-density lipoprotein particle mediated signaling IEA
 biological_processGO:0060100 positive regulation of phagocytosis, engulfment IEA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070508 cholesterol import ISS
 biological_processGO:0070542 response to fatty acid ISS
 biological_processGO:0070543 response to linoleic acid ISS
 biological_processGO:0071221 cellular response to bacterial lipopeptide IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus ISS
 biological_processGO:0071447 cellular response to hydroperoxide IEA
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IDA
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IMP
 biological_processGO:0150024 oxidised low-density lipoprotein particle clearance IMP
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly ISS
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process ISS
 biological_processGO:1904646 cellular response to amyloid-beta IGI
 biological_processGO:1990000 amyloid fibril formation ISS
 biological_processGO:2000121 regulation of removal of superoxide radicals IEA
 biological_processGO:2000334 positive regulation of blood microparticle formation IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IPI
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISS
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030666 endocytic vesicle membrane TAS
 cellular_componentGO:0031092 platelet alpha granule membrane TAS
 cellular_componentGO:0031526 brush border membrane ISS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0043235 receptor complex IPI
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0045335 phagocytic vesicle TAS
 molecular_functionGO:0001540 amyloid-beta binding TAS
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity TAS
 molecular_functionGO:0005044 scavenger receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008035 high-density lipoprotein particle binding IEA
 molecular_functionGO:0008289 lipid binding IDA
 molecular_functionGO:0030169 low-density lipoprotein particle binding IDA
 molecular_functionGO:0035325 Toll-like receptor binding IPI
 molecular_functionGO:0050431 transforming growth factor beta binding ISS
 molecular_functionGO:0070053 thrombospondin receptor activity ISS
 molecular_functionGO:0070892 lipoteichoic acid receptor activity IEA
 molecular_functionGO:0071813 lipoprotein particle binding IDA
 molecular_functionGO:0150025 oxidised low-density lipoprotein particle receptor activity IMP


Pathways (from Reactome)
Pathway description
Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
PPARA activates gene expression
Scavenging by Class B Receptors
Transcriptional regulation of white adipocyte differentiation
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000818 Endocrine abnormality 
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 HP:0001873 Thrombocytopenia 
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 HP:0001902 Giant platelets 
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 HP:0003010 Prolonged bleeding time 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex
 ENSG00000174130 TLR6 / Q9Y2C9 / toll like receptor 6  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction / complex
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction






 

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