ENSG00000150455


Homo sapiens

Features
Gene ID: ENSG00000150455
  
Biological name :TIRAP
  
Synonyms : P58753 / TIRAP / TIR domain containing adaptor protein
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q24.2
Gene start: 126283065
Gene end: 126298845
  
Corresponding Affymetrix probe sets: 1552360_a_at (Human Genome U133 Plus 2.0 Array)   1552804_a_at (Human Genome U133 Plus 2.0 Array)   1554091_a_at (Human Genome U133 Plus 2.0 Array)   239796_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000376445
Ensembl peptide - ENSP00000376447
Ensembl peptide - ENSP00000436967
Ensembl peptide - ENSP00000446213
Ensembl peptide - ENSP00000376446
NCBI entrez gene - 114609     See in Manteia.
OMIM - 606252
RefSeq - XM_017017162
RefSeq - NM_001039661
RefSeq - NM_001318776
RefSeq - NM_001318777
RefSeq - NM_148910
RefSeq - XM_005271399
RefSeq - XM_011542576
RefSeq Peptide - NP_683708
RefSeq Peptide - NP_001305706
RefSeq Peptide - NP_001305705
RefSeq Peptide - NP_001034750
swissprot - F5H2K1
swissprot - P58753
swissprot - A0A024R3M4
Ensembl - ENSG00000150455
  
Related genetic diseases (OMIM): 607948 - {Tuberculosis, protection against}, 607948
  610799 - {Pneumococcal disease, invasive, protection against}, 610799
  611162 - {Malaria, protection against}, 611162
  614382 - {Bacteremia, protection against}, 614382
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tirapENSDARG00000074371Danio rerio
 TIRAPENSGALG00000040224Gallus gallus
 TirapENSMUSG00000032041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR017279  Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway ISS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IMP
 biological_processGO:0030099 myeloid cell differentiation ISS
 biological_processGO:0030890 positive regulation of B cell proliferation ISS
 biological_processGO:0032496 response to lipopolysaccharide IDA
 biological_processGO:0032648 regulation of interferon-beta production ISS
 biological_processGO:0032735 positive regulation of interleukin-12 production ISS
 biological_processGO:0032738 positive regulation of interleukin-15 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IMP
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway ISS
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IMP
 biological_processGO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway IDA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0044130 negative regulation of growth of symbiont in host ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045088 regulation of innate immune response IC
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium ISS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IDA
 biological_processGO:0071221 cellular response to bacterial lipopeptide ISS
 biological_processGO:0071223 cellular response to lipoteichoic acid ISS
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis ISS
 biological_processGO:0090073 positive regulation of protein homodimerization activity IDA
 biological_processGO:2000340 positive regulation of chemokine (C-X-C motif) ligand 1 production ISS
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0032587 ruffle membrane ISS
 molecular_functionGO:0005080 protein kinase C binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS
 molecular_functionGO:0030674 protein binding, bridging NAS
 molecular_functionGO:0035662 Toll-like receptor 4 binding IPI
 molecular_functionGO:0035663 Toll-like receptor 2 binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
MyD88:Mal cascade initiated on plasma membrane
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000137462 TLR2 / O60603 / toll like receptor 2  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000135218 CD36 / P16671 / CD36 molecule  / complex / reaction
 ENSG00000174125 TLR1 / Q15399 / toll like receptor 1  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / reaction / complex
 ENSG00000010671 BTK / Q06187 / Bruton tyrosine kinase  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000174130 TLR6 / Q9Y2C9 / toll like receptor 6  / reaction / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000150455 TIRAP / P58753 / TIR domain containing adaptor protein  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex






 

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