ENSMUSG00000032041


Mus musculus

Features
Gene ID: ENSMUSG00000032041
  
Biological name :Tirap
  
Synonyms : Tirap / toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  
Possible biological names infered from orthology : P58753 / TIR domain containing adaptor protein
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A4
Gene start: 35184551
Gene end: 35200291
  
Corresponding Affymetrix probe sets: 10592106 (MoGene1.0st)   1418685_at (Mouse Genome 430 2.0 Array)   1457676_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135876
Ensembl peptide - ENSMUSP00000134984
Ensembl peptide - ENSMUSP00000135224
Ensembl peptide - ENSMUSP00000135429
Ensembl peptide - ENSMUSP00000135435
Ensembl peptide - ENSMUSP00000135462
Ensembl peptide - ENSMUSP00000135738
NCBI entrez gene - 117149     See in Manteia.
MGI - MGI:2152213
RefSeq - NM_054096
RefSeq - NM_001177847
RefSeq - NM_001177846
RefSeq - NM_001177845
RefSeq Peptide - NP_473437
RefSeq Peptide - NP_001171316
RefSeq Peptide - NP_001171317
RefSeq Peptide - NP_001171318
swissprot - H3BJH1
swissprot - H3BLC8
swissprot - H3BKL1
swissprot - H3BKK6
Ensembl - ENSMUSG00000032041
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tirapENSDARG00000074371Danio rerio
 TIRAPENSGALG00000040224Gallus gallus
 TIRAPENSG00000150455Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR017279  Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032738 positive regulation of interleukin-15 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035662 Toll-like receptor 4 binding IEA
 molecular_functionGO:0035663 Toll-like receptor 2 binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
MyD88:Mal cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tiraptm1Medz/Tiraptm1Medz
Genetic Background: involves: 129S1/Sv

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Tiraptm1Aki/Tiraptm1Aki
Genetic Background: B6.129P2-Tiraptm1Aki

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

Allelic Composition: Tiraptm1Medz/Tiraptm1Medz
Genetic Background: involves: 129S1/Sv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dcntm1Ioz/Dcn+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129/Sv * Black Swiss * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Vdrtm1Mbd/Vdrtm1Mbd
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Tiraptm1Aki/Tiraptm1Aki
Genetic Background: B6.129P2-Tiraptm1Aki

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Tiraptm1Aki/Tiraptm1Aki
Genetic Background: B6.129P2-Tiraptm1Aki

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il6sttm1Ern/Il6sttm1Ern,Tiraptm1.1Pjh/Tiraptm1.1Pjh
Genetic Background: involves: 129S1/Sv

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tiraptm1Medz/Tiraptm1Medz
Genetic Background: involves: 129S1/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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