ENSGALG00000040224


Gallus gallus

Features
Gene ID: ENSGALG00000040224
  
Biological name :TIRAP
  
Synonyms : TIRAP / TIR domain containing adaptor protein
  
Possible biological names infered from orthology : P58753 / toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
  
Species: Gallus gallus
  
Chr. number: 24
Strand: 1
Band:
Gene start: 415562
Gene end: 420117
  
Corresponding Affymetrix probe sets: Gga.12311.2.S1_x_at (Chicken Array)   Gga.12311.5.S1_a_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046832
Ensembl peptide - ENSGALP00000048558
Ensembl peptide - ENSGALP00000050147
Ensembl peptide - ENSGALP00000062118
NCBI entrez gene - 419715     See in Manteia.
RefSeq - XM_015297985
RefSeq - NM_001024829
RefSeq - XM_015297983
RefSeq - XM_015297984
RefSeq - XM_015297977
RefSeq - XM_015297978
RefSeq - XM_015297979
RefSeq - XM_015297980
RefSeq - XM_015297981
RefSeq - XM_015297982
RefSeq Peptide - NP_001020000
swissprot - Q4U127
Ensembl - ENSGALG00000040224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tirapENSDARG00000074371Danio rerio
 TIRAPENSG00000150455Homo sapiens
 TirapENSMUSG00000032041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR017279  Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway NAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032738 positive regulation of interleukin-15 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035665 TIRAP-dependent toll-like receptor 4 signaling pathway IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization IEA
 biological_processGO:0090073 positive regulation of protein homodimerization activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0035662 Toll-like receptor 4 binding IEA
 molecular_functionGO:0035663 Toll-like receptor 2 binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
MyD88:Mal cascade initiated on plasma membrane
NFkB and MAPK activation mediated by TRAF6
MyD88:TIRAP-dependent cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex / reaction
 ENSGALG00000040224 TIRAP / TIR domain containing adaptor protein / P58753* / toll-interleukin 1 receptor (TIR) domain-containing adaptor protein*  / reaction / complex






 

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