ENSGALG00000005947


Gallus gallus

Features
Gene ID: ENSGALG00000005947
  
Biological name :MYD88
  
Synonyms : A5HNF6 / MYD88 / Myeloid differentiation primary response protein MyD88
  
Possible biological names infered from orthology : myeloid differentiation primary response 88 / myeloid differentiation primary response gene 88 / P22366 / Q99836
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 4841182
Gene end: 4853799
  
Corresponding Affymetrix probe sets: Gga.17397.1.S1_at (Chicken Array)   GgaAffx.3703.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000042597
Ensembl peptide - ENSGALP00000058984
NCBI entrez gene - 420420     See in Manteia.
RefSeq - NM_001030962
RefSeq Peptide - NP_001026133
swissprot - A5HNF6
swissprot - A0A1L1RJR5
Ensembl - ENSGALG00000005947
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myd88ENSDARG00000010169Danio rerio
 MYD88ENSG00000172936Homo sapiens
 Myd88ENSMUSG00000032508Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000488  Death domain
 IPR011029  Death-like domain superfamily
 IPR017281  Myeloid differentiation primary response protein MyD88


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002238 response to molecule of fungal origin IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009682 induced systemic resistance IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032494 response to peptidoglycan IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032675 regulation of interleukin-6 production IEA
 biological_processGO:0032680 regulation of tumor necrosis factor production IEA
 biological_processGO:0032740 positive regulation of interleukin-17 production IEA
 biological_processGO:0032747 positive regulation of interleukin-23 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045351 type I interferon biosynthetic process IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0090557 establishment of endothelial intestinal barrier IEA
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IEA
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1902622 regulation of neutrophil migration IEA
 biological_processGO:2000338 regulation of chemokine (C-X-C motif) ligand 1 production IEA
 biological_processGO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0035325 Toll-like receptor binding IEA
 molecular_functionGO:0070976 TIR domain binding IEA


Pathways (from Reactome)
Pathway description
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
NFkB and MAPK activation mediated by TRAF6
MyD88-dependent cascade initiated on endosome membrane
MyD88:TIRAP-dependent cascade initiated on plasma membrane
NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation
TICAM1-dependent activation of IRF3/IRF7
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002556 NGF / nerve growth factor / P01138* / P01139* / Beta-nerve growth factor *  / complex
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / reaction
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSGALG00000016590 TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*  / reaction / complex
 ENSGALG00000009586 IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000043082 DHX36 / DEAH-box helicase 36 / Q8VHK9* / Q9H2U1* / ATP-dependent RNA helicase DHX36 *  / reaction / complex
 ENSGALG00000035950 NGFR / P18519 / Tumor necrosis factor receptor superfamily member 16 / P08138* / nerve growth factor receptor*  / complex
 ENSGALG00000040224 TIRAP / TIR domain containing adaptor protein / P58753* / toll-interleukin 1 receptor (TIR) domain-containing adaptor protein*  / complex / reaction
 ENSGALG00000043044 IL1R1 / interleukin-1 receptor type 1 precursor / P14778* / P13504* / interleukin 1 receptor type 1* / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleuki...  / complex / reaction
 ENSGALG00000007253 IL1RAP / interleukin 1 receptor accessory protein / Q61730* / Q9NPH3*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex / reaction
 ENSGALG00000030526 IL1R1* / P13504* / P14778* / interleukin 1 receptor type 1* / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form*  / complex / reaction
 ENSGALG00000029940 IL1B / interleukin 1 beta / P01584* / P10749*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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