ENSDARG00000010169


Danio rerio

Features
Gene ID: ENSDARG00000010169
  
Biological name :myd88
  
Synonyms : myd88 / myeloid differentiation primary response 88
  
Possible biological names infered from orthology : myeloid differentiation primary response gene 88 / P22366 / Q99836
  
Species: Danio rerio
  
Chr. number: 24
Strand: -1
Band:
Gene start: 20188914
Gene end: 20192996
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000020711
swissprot - A0A0R4I9A6
ZFIN ID - ZDB-GENE-040219-3
Ensembl - ENSDARG00000010169
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MYD88ENSGALG00000005947Gallus gallus
 MYD88ENSG00000172936Homo sapiens
 Myd88ENSMUSG00000032508Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000488  Death domain
 IPR011029  Death-like domain superfamily
 IPR017281  Myeloid differentiation primary response protein MyD88
 IPR034249  MyD88, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0070976 TIR domain binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
RIP-mediated NFkB activation via ZBP1
p75NTR recruits signalling complexes
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000033 intermediate cell mass of mesoderm intermediate cell mass of mesoderm hematopoietic multipotent progenitor cell decreased amount , abnormal
intermediate cell mass of mesoderm hematopoietic cell decreased amount , abnormal
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 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle monocyte chemotaxis decreased occurrence , abnormal
fourth ventricle monocyte decreased amount , abnormal
fourth ventricle neutrophil decreased amount , abnormal
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 ZFA:0000243 neuromast neuromast epithelium position , ameliorated
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 ZFA:0000554 olfactory epithelium olfactory epithelium position , ameliorated
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
whole organism neutrophil decreased amount , abnormal
whole organism decreased life span , exacerbated
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 ZFA:0001114 head head epidermis position , ameliorated
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell decreased amount , abnormal
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 ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium cellular quality , abnormal
Show

 ZFA:0009000 cell cell autophagosome decreased amount , abnormal
Show

 ZFA:0009034 epithelial cell epithelial cell position , ameliorated
Show

 ZFA:0009046 T cell T cell decreased amount , abnormal
Show

 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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