ENSGALG00000009586


Gallus gallus

Features
Gene ID: ENSGALG00000009586
  
Biological name :IRAK4
  
Synonyms : interleukin-1 receptor-associated kinase 4 / IRAK4
  
Possible biological names infered from orthology : Q8R4K2 / Q9NWZ3
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 30069844
Gene end: 30081296
  
Corresponding Affymetrix probe sets: GgaAffx.12511.1.S1_at (Chicken Array)   GgaAffx.6017.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000015600
Ensembl peptide - ENSGALP00000015599
NCBI entrez gene - 417796     See in Manteia.
RefSeq - XM_015281244
RefSeq - NM_001030738
RefSeq Peptide - NP_001025909
swissprot - E1C1A7
swissprot - F1P2L8
Ensembl - ENSGALG00000009586
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRAK4ENSDARG00000100534Danio rerio
 IRAK4ENSG00000198001Homo sapiens
 Irak4ENSMUSG00000059883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*ENSGALG0000000840725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017428  Interleukin-1 receptor-associated kinase 4
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002446 neutrophil mediated immunity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IBA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IBA
 biological_processGO:1990266 neutrophil migration IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005149 interleukin-1 receptor binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / reaction / complex
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / reaction / complex
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSGALG00000016590 TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*  / complex / reaction
 ENSGALG00000012124 PELI2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*  / complex / reaction
 ENSGALG00000007253 IL1RAP / interleukin 1 receptor accessory protein / Q61730* / Q9NPH3*  / complex / reaction
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / reaction / complex
 ENSGALG00000029940 IL1B / interleukin 1 beta / P01584* / P10749*  / complex / reaction
 ENSGALG00000030526 IL1R1* / P13504* / P14778* / interleukin 1 receptor type 1* / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleukin-1 receptor type 1, soluble form*  / reaction / complex
 ENSGALG00000009586 IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*  / complex / reaction
 ENSGALG00000043044 IL1R1 / interleukin-1 receptor type 1 precursor / P14778* / P13504* / interleukin 1 receptor type 1* / Interleukin-1 receptor type 1 Interleukin-1 receptor type 1, membrane form Interleuki...  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction / complex
 ENSGALG00000008837 PELI1 / E3 ubiquitin-protein ligase pellino homolog 1 / Q8C669* / Q96FA3* / pellino 1* / pellino E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / complex / reaction






 

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