ENSDARG00000100534


Danio rerio

Features
Gene ID: ENSDARG00000100534
  
Biological name :IRAK4
  
Synonyms : interleukin 1 receptor associated kinase 4 / IRAK4
  
Possible biological names infered from orthology : Q8R4K2 / Q9NWZ3
  
Species: Danio rerio
  
Chr. number: 25
Strand: -1
Band:
Gene start: 768014
Gene end: 774471
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000135636
Ensembl peptide - ENSDARP00000136170
swissprot - A0A0R4IP49
swissprot - A0A0R4IQ44
Ensembl - ENSDARG00000100534
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRAK4ENSGALG00000009586Gallus gallus
 IRAK4ENSG00000198001Homo sapiens
 Irak4ENSMUSG00000059883Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*ENSDARG0000002594925
irak3 / interleukin-1 receptor-associated kinase 3 / Q8K4B2* / Q9Y616* / Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3), transcript variant 2, mRNA.*ENSDARG0000005313124


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR017428  Interleukin-1 receptor-associated kinase 4
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-1 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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