ENSDARG00000053131


Danio rerio

Features
Gene ID: ENSDARG00000053131
  
Biological name :irak3
  
Synonyms : interleukin-1 receptor-associated kinase 3 / irak3
  
Possible biological names infered from orthology : Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3), transcript variant 2, mRNA. / Q8K4B2 / Q9Y616
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 12782134
Gene end: 12790990
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000067130
Ensembl peptide - ENSDARP00000151565
Ensembl peptide - ENSDARP00000156698
NCBI entrez gene - 567444     See in Manteia.
swissprot - B0UYS2
ZFIN ID - ZDB-GENE-060503-710
Ensembl - ENSDARG00000053131
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRAK3ENSG00000090376Homo sapiens
 Irak3ENSMUSG00000020227Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
irak1 / interleukin-1 receptor-associated kinase 1 / P51617* / Q62406*ENSDARG0000002594926
IRAK4 / interleukin 1 receptor associated kinase 4 / Q9NWZ3*ENSDARG0000010053417


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR033610  Interleukin-1 receptor-associated kinase 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043407 negative regulation of MAP kinase activity IBA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IBA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000186 common cardinal vein common cardinal vein morphology , abnormal
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 ZFA:0009044 blood cell blood cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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