ENSG00000090376


Homo sapiens

Features
Gene ID: ENSG00000090376
  
Biological name :IRAK3
  
Synonyms : interleukin 1 receptor associated kinase 3 / IRAK3 / Q9Y616
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q14.3
Gene start: 66188879
Gene end: 66254622
  
Corresponding Affymetrix probe sets: 1568830_at (Human Genome U133 Plus 2.0 Array)   213817_at (Human Genome U133 Plus 2.0 Array)   220034_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000409852
Ensembl peptide - ENSP00000261233
Ensembl peptide - ENSP00000441321
NCBI entrez gene - 11213     See in Manteia.
OMIM - 604459
RefSeq - NM_007199
RefSeq - NM_001142523
RefSeq Peptide - NP_001135995
RefSeq Peptide - NP_009130
swissprot - Q9Y616
swissprot - F5GYN6
Ensembl - ENSG00000090376
  
Related genetic diseases (OMIM): 611064 - {Asthma susceptibility 5}, 611064
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irak3ENSDARG00000053131Danio rerio
 Irak3ENSMUSG00000020227Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IRAK1 / P51617 / interleukin 1 receptor associated kinase 1ENSG0000018421628
IRAK2 / O43187 / interleukin 1 receptor associated kinase 2ENSG0000013407022
IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4ENSG0000019800121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR033610  Interleukin-1 receptor-associated kinase 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway IC
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009615 response to virus IC
 biological_processGO:0010933 positive regulation of macrophage tolerance induction ISS
 biological_processGO:0010936 negative regulation of macrophage cytokine production ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032494 response to peptidoglycan ISS
 biological_processGO:0032496 response to lipopolysaccharide ISS
 biological_processGO:0032695 negative regulation of interleukin-12 production ISS
 biological_processGO:0032715 negative regulation of interleukin-6 production ISS
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway ISS
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0043242 negative regulation of protein complex disassembly IMP
 biological_processGO:0043244 regulation of protein complex disassembly ISS
 biological_processGO:0043330 response to exogenous dsRNA ISS
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0045824 negative regulation of innate immune response ISS
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IMP
 biological_processGO:0070555 response to interleukin-1 IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
MyD88:Mal cascade initiated on plasma membrane
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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