ENSMUSG00000020227


Mus musculus

Features
Gene ID: ENSMUSG00000020227
  
Biological name :Irak3
  
Synonyms : Irak3 / Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3), transcript variant 2, mRNA. / Q8K4B2
  
Possible biological names infered from orthology : interleukin 1 receptor associated kinase 3 / Q9Y616
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 120141648
Gene end: 120202130
  
Corresponding Affymetrix probe sets: 10372781 (MoGene1.0st)   1430704_at (Mouse Genome 430 2.0 Array)   1435040_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123604
Ensembl peptide - ENSMUSP00000020448
Ensembl peptide - ENSMUSP00000118038
NCBI entrez gene - 73914     See in Manteia.
MGI - MGI:1921164
RefSeq - XM_006514228
RefSeq - NM_001359184
RefSeq - NM_028679
RefSeq - XM_006514227
RefSeq Peptide - NP_001346113
RefSeq Peptide - NP_082955
swissprot - Q0VB14
swissprot - D6RCU1
swissprot - Q8K4B2
swissprot - D3Z007
Ensembl - ENSMUSG00000020227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irak3ENSDARG00000053131Danio rerio
 IRAK3ENSG00000090376Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*ENSMUSG0000003139227
Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*ENSMUSG0000006047720
Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*ENSMUSG0000005988320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR033610  Interleukin-1 receptor-associated kinase 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway IC
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process RCA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009615 response to virus IC
 biological_processGO:0010933 positive regulation of macrophage tolerance induction IMP
 biological_processGO:0010936 negative regulation of macrophage cytokine production IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032494 response to peptidoglycan IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0034122 negative regulation of toll-like receptor signaling pathway IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IEA
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0043242 negative regulation of protein complex disassembly IEA
 biological_processGO:0043244 regulation of protein complex disassembly IDA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0002869 increased insulin autoantibody level "elevated level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

 MP:0008136 enlarged Peyer s patches "increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008152 decreased diameter of femur "reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pth1rtm1Hmk/Pth1rtm1Hmk
Genetic Background: involves: 129X1/SvJ * Black Swiss * C57BL/6

 MP:0013772 increased effector memory T-helper cell number "increase in the number of CD4-positive alpha-beta T-helper cells with a CD44-positive, CD62L-negative memory phenotype" [MGI:Saran]
Show

Allelic Composition: Shank3tm1d(KOMP)Mbp/Shank3tm1d(KOMP)Mbp
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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