ENSMUSG00000060477


Mus musculus

Features
Gene ID: ENSMUSG00000060477
  
Biological name :Irak2
  
Synonyms : Interleukin-1 receptor-associated kinase-like 2 / Irak2 / Q8CFA1
  
Possible biological names infered from orthology : interleukin 1 receptor associated kinase 2 / O43187
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E3
Gene start: 113638467
Gene end: 113695026
  
Corresponding Affymetrix probe sets: 10540795 (MoGene1.0st)   1436507_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144848
Ensembl peptide - ENSMUSP00000055073
Ensembl peptide - ENSMUSP00000086416
Ensembl peptide - ENSMUSP00000086417
NCBI entrez gene - 108960     See in Manteia.
MGI - MGI:2429603
RefSeq - XM_006505325
RefSeq - NM_001113553
RefSeq - NM_172161
RefSeq Peptide - NP_001107025
RefSeq Peptide - NP_751893
swissprot - Q8CFA1
swissprot - A0A0N4SUW3
Ensembl - ENSMUSG00000060477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRAK2ENSGALG00000008407Gallus gallus
 IRAK2ENSG00000134070Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*ENSMUSG0000003139227
Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*ENSMUSG0000005988319
Irak3 / Q8K4B2 / Mus musculus interleukin-1 receptor-associated kinase 3 (Irak3), transcript variant 2, mRNA. / Q9Y616* / interleukin 1 receptor associated kinase 3*ENSMUSG0000002022719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011029  Death-like domain superfamily
 IPR033611  Interleukin-1 receptor-associated kinase-like 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001959 regulation of cytokine-mediated signaling pathway IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042981 regulation of apoptotic process RCA
 biological_processGO:0043433 negative regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0070555 response to interleukin-1 ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Irak1tm1Jth/Y,Irak2tm1Aki/Irak2tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrp1rgsc799/Tyrp1rgsc799
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Irak1tm1Jth/Y,Irak2tm1Aki/Irak2tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Kmt2atm1Sjk/Kmt2atm1Sjk
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Irak1tm1.1Pcoh/?,Irak2tm1.1Pcoh/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Cebpam4443Dajl/Cebpam4443Dajl
Genetic Background: involves: C3H/HeSnJ * C57BL/6J * SWR

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrp1rgsc799/Tyrp1rgsc799
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Irak1tm1Jth/Y,Irak2tm1Aki/Irak2tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Irak2tm1Jth/Irak2tm1Jth
Genetic Background: involves: 129 * C57BL/6

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Irak2tm1Jth/Irak2tm1Jth
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / reaction / complex
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000044583 Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*  / complex / reaction
 ENSMUSG00000045322 Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*  / complex / reaction
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction
 ENSMUSG00000040522 Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction






 

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