ENSMUSG00000040522


Mus musculus

Features
Gene ID: ENSMUSG00000040522
  
Biological name :Tlr8
  
Synonyms : P58682 / Tlr8 / Toll-like receptor 8
  
Possible biological names infered from orthology : Q9NR97
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 167242696
Gene end: 167264329
  
Corresponding Affymetrix probe sets: 10607868 (MoGene1.0st)   1450267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122089
Ensembl peptide - ENSMUSP00000036762
Ensembl peptide - ENSMUSP00000107793
NCBI entrez gene - 170744     See in Manteia.
MGI - MGI:2176887
RefSeq - NM_001313760
RefSeq - NM_133212
RefSeq Peptide - NP_001300689
RefSeq Peptide - NP_573475
swissprot - A2AHI8
swissprot - P58682
Ensembl - ENSMUSG00000040522
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLR8ENSDARG00000104832Danio rerio
 tlr8bENSDARG00000073675Danio rerio
 TLR8ENSG00000101916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458343
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532234
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163922
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377721
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900519
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799517
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916417
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149817
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482715
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026906  Leucine rich repeat 5
 IPR027175  Toll-like receptor 8
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001932 regulation of protein phosphorylation IGI
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling ISO
 biological_processGO:0009615 response to virus ISO
 biological_processGO:0034158 toll-like receptor 8 signaling pathway ISO
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process ISS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response ISS
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process ISS
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process ISO
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process ISS
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISO
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion ISO
 biological_processGO:2001183 negative regulation of interleukin-12 secretion ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003725 double-stranded RNA binding ISS
 molecular_functionGO:0003727 single-stranded RNA binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002870 decreased insulin autoantibody level "reduced level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr8/Tlr7tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tlr8/Tlr7tm1Vlcg/Tlr7+,Tlr8/Tlr7tm1Vlcg/Tlr8tm1Vlcg
Genetic Background: B6.Cg-Tlr8/Tlr7tm1Vlcg Tlr8tm1Vlcg

 MP:0008206 increased B-2 cell number "greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex / reaction
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / complex / reaction
 ENSMUSG00000060477 Irak2 / Q8CFA1 / Interleukin-1 receptor-associated kinase-like 2 / O43187* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSMUSG00000040522 Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*  / complex
 ENSMUSG00000036908 Unc93b1 / unc-93 homolog B1 (C. elegans) / Q9H1C4* / unc-93 homolog B1, TLR signaling regulator*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr