ENSMUSG00000044827


Mus musculus

Features
Gene ID: ENSMUSG00000044827
  
Biological name :Tlr1
  
Synonyms : Q9EPQ1 / Tlr1 / toll-like receptor 1
  
Possible biological names infered from orthology : Q15399
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 64924679
Gene end: 64933563
  
Corresponding Affymetrix probe sets: 10530145 (MoGene1.0st)   1449049_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060793
Ensembl peptide - ENSMUSP00000142500
NCBI entrez gene - 21897     See in Manteia.
MGI - MGI:1341295
RefSeq - XM_011240720
RefSeq - NM_001276445
RefSeq - NM_030682
RefSeq - XM_006503852
RefSeq - XM_006503853
RefSeq - XM_006503854
RefSeq - XM_006503856
RefSeq - XM_006503851
RefSeq Peptide - NP_001263374
RefSeq Peptide - NP_109607
swissprot - Q9EPQ1
swissprot - B9EJ46
Ensembl - ENSMUSG00000044827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr1ENSDARG00000100649Danio rerio
 TLR1AENSGALG00000017485Gallus gallus
 TLR1BENSGALG00000027093Gallus gallus
 TLR1ENSG00000174125Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149866
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799528
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900522
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377722
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163921
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532220
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052219
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916419
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458318
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162412


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR025875  Leucine rich repeat 4
 IPR027190  Toll-like receptor 1
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001775 cell activation ISO
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity NAS
 biological_processGO:0034130 toll-like receptor 1 signaling pathway IEA
 biological_processGO:0034137 positive regulation of toll-like receptor 2 signaling pathway ISO
 biological_processGO:0042116 macrophage activation NAS
 biological_processGO:0042495 detection of triacyl bacterial lipopeptide NAS
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IMP
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IMP
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0071727 cellular response to triacyl bacterial lipopeptide IBA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030670 phagocytic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex IBA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0045335 phagocytic vesicle NAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity NAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035663 Toll-like receptor 2 binding ISO
 molecular_functionGO:0042497 triacyl lipopeptide binding NAS
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0071723 lipopeptide binding IBA


Pathways (from Reactome)
Pathway description
Beta defensins
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl
Genetic Background: involves: 129S/SvEv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm3Wahl/Trp53tm3Wahl
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027995 Tlr2 / toll-like receptor 2 / O60603*  / complex
 ENSMUSG00000021789 Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*  / reaction / complex
 ENSMUSG00000046354 Defb14 / Q7TNV9 / Beta-defensin 14 / P81534* / DEFB103B* / DEFB103A* / defensin beta 103A* / defensin beta 103B*  / complex / reaction
 ENSMUSG00000021795 Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*  / reaction / complex






 

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