ENSMUSG00000031639


Mus musculus

Features
Gene ID: ENSMUSG00000031639
  
Biological name :Tlr3
  
Synonyms : Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / Q99MB1 / Tlr3
  
Possible biological names infered from orthology : O15455 / toll like receptor 3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: B1.1
Gene start: 45395665
Gene end: 45411080
  
Corresponding Affymetrix probe sets: 10578493 (MoGene1.0st)   1422781_at (Mouse Genome 430 2.0 Array)   1422782_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147783
Ensembl peptide - ENSMUSP00000147738
Ensembl peptide - ENSMUSP00000147961
Ensembl peptide - ENSMUSP00000148263
Ensembl peptide - ENSMUSP00000148127
Ensembl peptide - ENSMUSP00000034056
Ensembl peptide - ENSMUSP00000126556
NCBI entrez gene - 142980     See in Manteia.
MGI - MGI:2156367
RefSeq - XM_006509283
RefSeq - NM_001357316
RefSeq - NM_001357317
RefSeq - NM_126166
RefSeq - XM_006509278
RefSeq - XM_006509279
RefSeq - XM_006509280
RefSeq - XM_006509281
RefSeq - XM_006509282
RefSeq Peptide - NP_569054
RefSeq Peptide - NP_001344245
RefSeq Peptide - NP_001344246
swissprot - A0A1Y7VI41
swissprot - A0A1B0GS40
swissprot - Q99MB1
swissprot - A0A1B0GTA2
swissprot - A0A1B0GSY9
Ensembl - ENSMUSG00000031639
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr3ENSDARG00000016065Danio rerio
 TLR3ENSGALG00000013468Gallus gallus
 TLR3ENSG00000164342Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458325
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052225
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532224
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377724
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916421
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900520
Tlr6 / toll-like receptor 6 / Q9Y2C9*ENSMUSG0000005149819
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482718
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799516
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027173  Toll-like receptor 3
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002730 regulation of dendritic cell cytokine production IDA
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway IEA
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation ISO
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0032481 positive regulation of type I interferon production IDA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production ISO
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway ISO
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034346 positive regulation of type III interferon production IDA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0043331 response to dsRNA IEA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process ISS
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process ISS
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process ISO
 biological_processGO:0045766 positive regulation of angiogenesis IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway ISO
 biological_processGO:0097527 necroptotic signaling pathway ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: involves: C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0003106 abnormal fear-related response "altered emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003459 increased fear-related response "greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003460 decreased fear-related response "reduced emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Mlphln-2Btlr/Mlphln-2Btlr
Genetic Background: C57BL/6J-Mlphln-2Btlr

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

Allelic Composition: Tlr3M2Btlr/Tlr3M2Btlr
Genetic Background: C57BL/6J-Tlr3M2Btlr

Allelic Composition: Tlr3M2Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M2Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Tlr3tm1Flv/Tlr3tm1Flv
Genetic Background: B6.129S1-Tlr3tm1Flv

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009669 abnormal postimplantation uterine environment "failure of the uterus to undergo the changes necessary to support pregnancy following implantation of the embryo" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmap1tm1.2Jrc/Dmap1+,Dnmt1tm2Jrc/Dnmt1tm2Jrc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N * SJL

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: Not Specified

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mlphln-2Btlr/Mlphln-2Btlr
Genetic Background: C57BL/6J-Mlphln-2Btlr

Allelic Composition: Tlr3M1Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036908 Unc93b1 / unc-93 homolog B1 (C. elegans) / Q9H1C4* / unc-93 homolog B1, TLR signaling regulator*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr