ENSMUSG00000051498


Mus musculus

Features
Gene ID: ENSMUSG00000051498
  
Biological name :Tlr6
  
Synonyms : Tlr6 / toll-like receptor 6
  
Possible biological names infered from orthology : Q9Y2C9
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 64952031
Gene end: 64960097
  
Corresponding Affymetrix probe sets: 10530151 (MoGene1.0st)   1421352_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062096
Ensembl peptide - ENSMUSP00000143865
NCBI entrez gene - 21899     See in Manteia.
MGI - MGI:1341296
RefSeq - XM_006503860
RefSeq - NM_001359180
RefSeq - NM_011604
RefSeq - XM_006503857
RefSeq - XM_006503858
RefSeq - XM_006503859
RefSeq Peptide - NP_001346109
RefSeq Peptide - NP_035734
swissprot - A0A0J9YTV4
swissprot - Q3UV88
Ensembl - ENSMUSG00000051498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr1ENSDARG00000100649Danio rerio
 TLR1AENSGALG00000017485Gallus gallus
 TLR1BENSGALG00000027093Gallus gallus
 TLR6ENSG00000174130Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*ENSMUSG0000004482765
Tlr2 / toll-like receptor 2 / O60603*ENSMUSG0000002799528
Tlr13 / Q6R5N8 / Toll-like receptor 13 ENSMUSG0000003377723
Tlr3 / Q99MB1 / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA. / O15455* / toll like receptor 3*ENSMUSG0000003163922
Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*ENSMUSG0000003900522
Tlr8 / P58682 / Toll-like receptor 8 / Q9NR97*ENSMUSG0000004052221
Tlr9 / Q9EQU3 / Toll-like receptor 9 / Q9NR96* / AC097637.1*ENSMUSG0000004532221
Tlr7 / P58681 / toll-like receptor 7 / Q9NYK1*ENSMUSG0000004458319
Tlr5 / toll-like receptor 5 / O60602*ENSMUSG0000007916418
Cd180 / Q62192 / CD180 antigen / Q99467* / CD180 molecule*ENSMUSG0000002162411


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR025875  Leucine rich repeat 4
 IPR027187  Toll-like receptor 6
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001775 cell activation IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032493 response to bacterial lipoprotein IEA
 biological_processGO:0034136 negative regulation of toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034150 toll-like receptor 6 signaling pathway IEA
 biological_processGO:0042088 T-helper 1 type immune response IEA
 biological_processGO:0042496 detection of diacyl bacterial lipopeptide IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process IEA
 biological_processGO:0046209 nitric oxide metabolic process IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IEA
 biological_processGO:1904646 cellular response to amyloid-beta IEA
 biological_processGO:2000483 negative regulation of interleukin-8 secretion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035663 Toll-like receptor 2 binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0071723 lipopeptide binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tlr6m3Btlr/Tlr6m3Btlr
Genetic Background: C57BL/6J-Tlr6m3Btlr

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox6tm2.2Vlf/Sox6tm2.2Vlf
Genetic Background: involves: 129 * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tlr6int/Tlr6int
Genetic Background: C57BL/6-Tlr6int

Allelic Composition: Tlr6m2Btlr/Tlr6m2Btlr
Genetic Background: C57BL/6J-Tlr6m2Btlr

Allelic Composition: Tlr6m3Btlr/Tlr6m3Btlr
Genetic Background: C57BL/6J-Tlr6m3Btlr

Allelic Composition: Tlr6m4Btlr/Tlr6m4Btlr
Genetic Background: C57BL/6J-Tlr6m4Btlr

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tlr6m2Btlr/Tlr6m2Btlr
Genetic Background: C57BL/6J-Tlr6m2Btlr

Allelic Composition: Tlr6m3Btlr/Tlr6m3Btlr
Genetic Background: C57BL/6J-Tlr6m3Btlr

Allelic Composition: Tlr6m4Btlr/Tlr6m4Btlr
Genetic Background: C57BL/6J-Tlr6m4Btlr

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tlr2tm1Aki/Tlr2tm1Aki,Tlr6tm1Aki/Tlr6tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex
 ENSMUSG00000002944 Cd36 / Q08857 / Platelet glycoprotein 4 / P16671* / CD36 molecule*  / complex / reaction






 

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