ENSG00000164342


Homo sapiens

Features
Gene ID: ENSG00000164342
  
Biological name :TLR3
  
Synonyms : O15455 / TLR3 / toll like receptor 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q35.1
Gene start: 186069152
Gene end: 186088069
  
Corresponding Affymetrix probe sets: 206271_at (Human Genome U133 Plus 2.0 Array)   239587_at (Human Genome U133 Plus 2.0 Array)   242667_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423386
Ensembl peptide - ENSP00000423684
Ensembl peptide - ENSP00000296795
NCBI entrez gene - 7098     See in Manteia.
OMIM - 603029
RefSeq - NM_003265
RefSeq - XM_017008577
RefSeq Peptide - NP_003256
swissprot - D6RA51
swissprot - O15455
Ensembl - ENSG00000164342
  
Related genetic diseases (OMIM): 609423 - {HIV1 infection, resistance to}, 609423
  613002 - {Encephalopathy, acute, infection-induced (herpes-specific), susceptibility to, 2}, 613002
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr3ENSDARG00000016065Danio rerio
 TLR3ENSGALG00000013468Gallus gallus
 Tlr3ENSMUSG00000031639Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666425
AC097637.1ENSG0000017336624
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191624
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973224
TLR5 / O60602 / toll like receptor 5ENSG0000018755421
TLR4 / O00206 / toll like receptor 4ENSG0000013686920
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413018
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412317
TLR2 / O60603 / toll like receptor 2ENSG0000013746217
TLR1 / Q15399 / toll like receptor 1ENSG0000017412517
CD180 / Q99467 / CD180 moleculeENSG0000013406114


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026906  Leucine rich repeat 5
 IPR027173  Toll-like receptor 3
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002730 regulation of dendritic cell cytokine production IEA
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006972 hyperosmotic response NAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity NAS
 biological_processGO:0007252 I-kappaB phosphorylation IDA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009597 detection of virus NAS
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0032481 positive regulation of type I interferon production IEA
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032728 positive regulation of interferon-beta production ISS
 biological_processGO:0032735 positive regulation of interleukin-12 production ISS
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISS
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway IDA
 biological_processGO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0034138 toll-like receptor 3 signaling pathway TAS
 biological_processGO:0034346 positive regulation of type III interferon production IEA
 biological_processGO:0035458 cellular response to interferon-beta IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0042742 defense response to bacterium TAS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043330 response to exogenous dsRNA IDA
 biological_processGO:0043331 response to dsRNA IEA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
 biological_processGO:0045080 positive regulation of chemokine biosynthetic process IEA
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process IDA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IMP
 biological_processGO:0045671 negative regulation of osteoclast differentiation NAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051607 defense response to virus TAS
 biological_processGO:0070266 necroptotic process TAS
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071359 cellular response to dsRNA IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:0097190 apoptotic signaling pathway TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:0097527 necroptotic signaling pathway IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane NAS
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036020 endolysosome membrane TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding NAS
 molecular_functionGO:0004888 transmembrane signaling receptor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 3 (TLR3) Cascade
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
TLR3 deficiency - HSE
UNC93B1 deficiency - HSE
TICAM1 deficiency - HSE
TRAF3 deficiency - HSE
TLR3-mediated TICAM1-dependent programmed cell death
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129465 RIPK3 / Q9Y572 / receptor interacting serine/threonine kinase 3  / complex / reaction
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / reaction
 ENSG00000110057 Q9H1C4 / UNC93B1 / unc-93 homolog B1, TLR signaling regulator  / complex / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / reaction / complex
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / complex / reaction
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / reaction
 ENSG00000213341 CHUK / O15111 / conserved helix-loop-helix ubiquitous kinase  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000136560 TANK / Q92844 / TRAF family member associated NFKB activator  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000168040 FADD / Q13158 / Fas associated via death domain  / reaction / complex
 ENSG00000004139 SARM1 / Q6SZW1 / sterile alpha and TIR motif containing 1  / reaction / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / reaction / complex
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / reaction / complex
 ENSG00000183735 TBK1 / Q9UHD2 / TANK binding kinase 1  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / reaction
 ENSG00000263528 IKBKE / Q14164 / inhibitor of nuclear factor kappa B kinase subunit epsilon  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr