ENSG00000004139


Homo sapiens

Features
Gene ID: ENSG00000004139
  
Biological name :SARM1
  
Synonyms : Q6SZW1 / SARM1 / sterile alpha and TIR motif containing 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 28364356
Gene end: 28404049
  
Corresponding Affymetrix probe sets: 213257_at (Human Genome U133 Plus 2.0 Array)   213259_s_at (Human Genome U133 Plus 2.0 Array)   234060_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000462228
Ensembl peptide - ENSP00000464166
Ensembl peptide - ENSP00000468032
Ensembl peptide - ENSP00000462479
NCBI entrez gene - 23098     See in Manteia.
OMIM - 607732
RefSeq - NM_015077
RefSeq Peptide - NP_055892
swissprot - Q6SZW1
swissprot - J3KRZ6
swissprot - J3KSG7
swissprot - J3QRE0
Ensembl - ENSG00000004139
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sarm1ENSDARG00000010610Danio rerio
 SARM1ENSGALG00000003595Gallus gallus
 Sarm1ENSMUSG00000050132Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001660  Sterile alpha motif domain
 IPR011989  Armadillo-like helical
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016024  Armadillo-type fold
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:1901214 regulation of neuron death IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IBA
 cellular_componentGO:0031315 extrinsic component of mitochondrial outer membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse ISS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / complex / reaction
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / reaction / complex
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction / complex
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / reaction / complex
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction






 

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