ENSMUSG00000050132


Mus musculus

Features
Gene ID: ENSMUSG00000050132
  
Biological name :Sarm1
  
Synonyms : Q6PDS3 / Sarm1 / Sterile alpha and TIR motif-containing protein 1
  
Possible biological names infered from orthology : Q6SZW1 / sterile alpha and TIR motif containing 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 78472330
Gene end: 78497754
  
Corresponding Affymetrix probe sets: 10388847 (MoGene1.0st)   1435466_at (Mouse Genome 430 2.0 Array)   1445644_at (Mouse Genome 430 2.0 Array)   1457450_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051059
Ensembl peptide - ENSMUSP00000103922
NCBI entrez gene - 237868     See in Manteia.
MGI - MGI:2136419
RefSeq - NM_001168521
RefSeq - NM_172795
RefSeq Peptide - NP_001161993
RefSeq Peptide - NP_766383
swissprot - Q6PDS3
Ensembl - ENSMUSG00000050132
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sarm1ENSDARG00000010610Danio rerio
 SARM1ENSGALG00000003595Gallus gallus
 SARM1ENSG00000004139Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001660  Sterile alpha motif domain
 IPR011989  Armadillo-like helical
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR016024  Armadillo-type fold
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 biological_processGO:1901214 regulation of neuron death IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IMP
 cellular_componentGO:0031315 extrinsic component of mitochondrial outer membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
MyD88-independent TLR4 cascade
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: SfnEr/Sfn+
Genetic Background: B6CBACa Aw-J/A-SfnEr/J

 MP:0008552 abnormal circulating tumor necrosis factor level "anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0020449 decreased microglial cell activation "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex / reaction
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction






 

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