Manteia - Molecule gene

ENSMUSG00000056130

Mus musculus

Features

Gene ID:	ENSMUSG00000056130

Biological name :	Ticam2

Synonyms :	Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2

Possible biological names infered from orthology :	Q86XR7 / toll like receptor adaptor molecule 2

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	C
Gene start:	46559155
Gene end:	46574533

Corresponding Affymetrix probe sets:	10458816 (MoGene1.0st)

Cross references:	Ensembl peptide - ENSMUSP00000066239 NCBI entrez gene - 225471 See in Manteia. MGI - MGI:3040056 RefSeq - NM_173394 RefSeq Peptide - NP_775570 swissprot - Q8BJQ4 Ensembl - ENSMUSG00000056130

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ticam1	ENSDARG00000102493	Danio rerio
Q86XR7	ENSG00000243414	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*	ENSMUSG00000047123	26

Protein motifs (from Interpro)

Interpro ID	Name
IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
IPR015720	TMP21-related
IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001817	regulation of cytokine production	IMP
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0032729	positive regulation of interferon-gamma production	IMP
biological_process	GO:0032755	positive regulation of interleukin-6 production	IDA
biological_process	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway	ISO
biological_process	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway	IEA
biological_process	GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway	IEA
biological_process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	ISO
biological_process	GO:0045087	innate immune response	IEA
biological_process	GO:0051607	defense response to virus	IMP
biological_process	GO:0070671	response to interleukin-12	IMP
biological_process	GO:0071222	cellular response to lipopolysaccharide	IEA
biological_process	GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production	ISO
biological_process	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production	IDA
biological_process	GO:2000494	positive regulation of interleukin-18-mediated signaling pathway	IMP
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005769	early endosome	ISO
cellular_component	GO:0005770	late endosome	ISS
cellular_component	GO:0005783	endoplasmic reticulum	ISO
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0045323	interleukin-1 receptor complex	ISO
molecular_function	GO:0005149	interleukin-1 receptor binding	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005543	phospholipid binding	IDA
molecular_function	GO:0046982	protein heterodimerization activity	ISO

Pathways (from Reactome)

Pathway description

via Death Receptors in the presence of ligand

Toll Like Receptor 4 (TLR4) Cascade

MyD88-independent TLR4 cascade

TRIF-mediated programmed cell death

Neutrophil degranulation

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

IKK complex recruitment mediated by RIP1

TRAF6-mediated induction of TAK1 complex within TLR4 complex

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nf1^tm1Tyj/Nf1^tm1Tyj,Rasa1^tm1Paw/Rasa1^tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
MP:0008555	abnormal interferon secretion	"anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]	Show Allelic Composition: Gata4^tm1.1Sad/Gata4^tm1.1Sad,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0008561	decreased tumor necrosis factor secretion	"reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Gata4^tm1.1Sad/Gata4^tm1.1Sad,Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Ticam2^M1Btlr/Ticam2^M1Btlr Genetic Background: C57BL/6J-Ticam2^M1Btlr Allelic Composition: Ticam2^M1Btlr/Ticam2⁺ Genetic Background: C57BL/6J-Ticam2^M1Btlr Allelic Composition: Ticam2^M3Btlr/Ticam2^M3Btlr Genetic Background: C57BL/6J-Ticam2^M3Btlr Allelic Composition: Ticam2^M3Btlr/Ticam2⁺ Genetic Background: C57BL/6J-Ticam2^M3Btlr
MP:0008658	decreased interleukin-1 beta secretion	"reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Muc2^m3Btlr/Muc2^m3Btlr Genetic Background: C57BL/6J-Muc2^m3Btlr Allelic Composition: Ticam2^M2Btlr/Ticam2⁺ Genetic Background: C57BL/6J-Ticam2^M2Btlr
MP:0008706	decreased interleukin-6 secretion	"reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Nf1^tm1Tyj/Nf1^tm1Tyj,Rasa1^tm1Paw/Rasa1^tm1Paw Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000004221	Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*	/ reaction / complex
ENSMUSG00000020115	Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*	/ reaction / complex
ENSMUSG00000022221	Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*	/ complex / reaction
ENSMUSG00000026029	Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*	/ reaction / complex
ENSMUSG00000022414	Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*	/ reaction / complex
ENSMUSG00000025199	Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*	/ complex / reaction
ENSMUSG00000021408	Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*	/ complex / reaction
ENSMUSG00000031077	Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*	/ reaction / complex
ENSMUSG00000028284	Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*	/ complex / reaction
ENSMUSG00000003184	Irf3 / P70671 / interferon regulatory factor 3 / Q14653*	/ reaction / complex
ENSMUSG00000027164	Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*	/ complex / reaction
ENSMUSG00000021277	Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*	/ complex / reaction
ENSMUSG00000025498	Irf7 / P70434 / interferon regulatory factor 7 / Q92985*	/ reaction / complex
ENSMUSG00000051439	Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*	/ reaction / complex
ENSMUSG00000025779	Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*	/ complex / reaction
ENSMUSG00000056130	Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*	/ reaction / complex
ENSMUSG00000047123	Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*	/ reaction / complex
ENSMUSG00000039005	Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*	/ reaction / complex
ENSMUSG00000050132	Sarm1 / Q6PDS3 / Sterile alpha and TIR motif-containing protein 1 / Q6SZW1* / sterile alpha and TIR motif containing 1*	/ reaction / complex
ENSMUSG00000042349	Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*	/ reaction / complex
ENSMUSG00000035476	Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*	/ complex / reaction
ENSMUSG00000064289	Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*	/ reaction / complex
ENSMUSG00000015755	Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr