ENSMUSG00000051439


Mus musculus

Features
Gene ID: ENSMUSG00000051439
  
Biological name :Cd14
  
Synonyms : Cd14 / Monocyte differentiation antigen CD14 / P10810
  
Possible biological names infered from orthology : CD14 molecule / P08571
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 36725074
Gene end: 36726736
  
Corresponding Affymetrix probe sets: 10458382 (MoGene1.0st)   1417268_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000056669
NCBI entrez gene - 12475     See in Manteia.
MGI - MGI:88318
RefSeq - NM_009841
RefSeq Peptide - NP_033971
swissprot - P10810
swissprot - Q4FJP7
Ensembl - ENSMUSG00000051439
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD14ENSGALG00000039140Gallus gallus
 CD14ENSG00000170458Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR016337  Monocyte differentiation antigen CD14
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002237 response to molecule of bacterial origin IDA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006898 receptor-mediated endocytosis IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IMP
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IMP
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045807 positive regulation of endocytosis IMP
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0071219 cellular response to molecule of bacterial origin IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0071726 cellular response to diacyl bacterial lipopeptide IEA
 biological_processGO:0071727 cellular response to triacyl bacterial lipopeptide IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:2000484 positive regulation of interleukin-8 secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0070891 lipoteichoic acid binding IEA
 molecular_functionGO:0071723 lipopeptide binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pik3r1tm1Lca/Pik3r1+,Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: C.129S1-CD14tm1Smg

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: B6.129S1-CD14tm1Smg

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd14tm1Frm/Cd14+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd14hdl/Cd14hdl
Genetic Background: C57BL/6-Cd14hdl

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: C.129S1-CD14tm1Smg

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: C.129S1-CD14tm1Smg

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnab1tm1Sva/Kcnab1tm1Sva
Genetic Background: B6.129-Kcnab1tm1Sva

Allelic Composition: Cd14tm1Frm/Cd14+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pik3r1tm1Lca/Pik3r1+,Pik3r2tm1Lca/Pik3r2tm1Lca
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Cd14tm1Frm/Cd14+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd14hdl/Cd14hdl
Genetic Background: C57BL/6-Cd14hdl

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Kcnab1tm1Sva/Kcnab1tm1Sva
Genetic Background: B6.129-Kcnab1tm1Sva

Allelic Composition: Cd14tm1Frm/Cd14+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd14hdl/Cd14hdl
Genetic Background: C57BL/6-Cd14hdl

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: C.129S1-CD14tm1Smg

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg,Tlr4Lps-d/Tlr4Lps-d
Genetic Background: C3.129S1-CD14tm1Smg

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Kcnab1tm1Sva/Kcnab1tm1Sva
Genetic Background: B6.129-Kcnab1tm1Sva

Allelic Composition: Cd14tm1Frm/Cd14+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd14tm1Frm/Cd14+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Cd14hdl/Cd14hdl
Genetic Background: C57BL/6-Cd14hdl

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
Show

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: involves: 129S1/Sv

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd14tm1Smg/Cd14tm1Smg
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0009878 decreased susceptibility to bone fracture "reduced probability that injury or disease will result in damaged or broken bones" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tlr4lps-n/Tlr4lps-n
Genetic Background: C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction / complex
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / reaction / complex
 ENSMUSG00000016024 Lbp / Q61805 / Lipopolysaccharide-binding protein / P18428*  / reaction
 ENSMUSG00000022221 Ripk3 / Q9QZL0 / receptor-interacting serine-threonine kinase 3 / Q9Y572*  / reaction / complex
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / reaction / complex
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / reaction / complex
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction / complex
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex / reaction
 ENSMUSG00000031077 Fadd / Q61160 / FAS-associated death domain protein / Q13158* / Fas associated via death domain*  / reaction / complex
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000050132 Sarm1 / Q6PDS3 / Sterile alpha and TIR motif-containing protein 1 / Q6SZW1* / sterile alpha and TIR motif containing 1*  / reaction / complex
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / complex / reaction
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / complex
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / reaction / complex
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction






 

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