ENSMUSG00000021277


Mus musculus

Features
Gene ID: ENSMUSG00000021277
  
Biological name :Traf3
  
Synonyms : Q60803 / TNF receptor-associated factor 3 / Traf3
  
Possible biological names infered from orthology : Q13114
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 111166370
Gene end: 111267153
  
Corresponding Affymetrix probe sets: 10398618 (MoGene1.0st)   1418587_at (Mouse Genome 430 2.0 Array)   1449149_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021706
Ensembl peptide - ENSMUSP00000058361
Ensembl peptide - ENSMUSP00000112517
Ensembl peptide - ENSMUSP00000119010
NCBI entrez gene - 22031     See in Manteia.
MGI - MGI:108041
RefSeq - XM_017315042
RefSeq - NM_001286122
RefSeq - NM_011632
RefSeq - XM_006515798
RefSeq - XM_006515799
RefSeq - XM_006515800
RefSeq - XM_006515801
RefSeq - XM_006515802
RefSeq Peptide - NP_001273051
RefSeq Peptide - NP_035762
swissprot - Q3UHJ1
swissprot - Q60803
swissprot - D3Z343
Ensembl - ENSMUSG00000021277
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 traf3ENSDARG00000022000Danio rerio
 TRAF3ENSGALG00000011389Gallus gallus
 TRAF3ENSG00000131323Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Traf5 / TNF receptor-associated factor 5 / O00463*ENSMUSG0000002663741
Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*ENSMUSG0000002694231
Traf1 / P39428 / TNF receptor-associated factor 1 / Q13077*ENSMUSG0000002687524
Traf4 / Q61382 / TNF receptor-associated factor 4 / Q9BUZ4*ENSMUSG0000001738623
Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*ENSMUSG0000002716421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001293  Zinc finger, TRAF-type
 IPR001841  Zinc finger, RING-type
 IPR002083  MATH/TRAF domain
 IPR008974  TRAF-like
 IPR012227  TNF receptor-associated factor TRAF
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017907  Zinc finger, RING-type, conserved site
 IPR018957  Zinc finger, C3HC4 RING-type
 IPR027128  TNF receptor-associated factor 3
 IPR037304  TRAF3, MATH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001817 regulation of cytokine production IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0030162 regulation of proteolysis IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032648 regulation of interferon-beta production IMP
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050688 regulation of defense response to virus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0035631 CD40 receptor complex IDA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0031996 thioesterase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

 MP:0001844 autoimmune response "condition in which cells and/or antibodies arise from and are directed against one s own tissues " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0002344 abnormal lymph node B cell domain "anomaly in the lymph node cortex in which B lymphocytes reside" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002420 abnormal adaptive immunity "anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

Allelic Composition: Tg(Lck-cre)I57Jxm/?,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: C57BL/6 * ICR * SJL

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Lck-cre)I57Jxm/?,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: C57BL/6 * ICR * SJL

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tg(Lck-cre)I57Jxm/?,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: C57BL/6 * ICR * SJL

 MP:0008102 lymph node hyperplasia "overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Traf2tm1Rbr/Traf2tm1Rbr,Traf3tm1Rbr/Traf3tm1Rbr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Traf3tm1Bshp/Traf3tm1Bshp,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Oca2p-un+J/Oca2p-un+J
Genetic Background: C57BL/6J-Oca2p-un

Allelic Composition: Nfkb2tm2Brv/Nfkb2+,Traf3tm1Bal/Traf3tm1Bal
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * C57BL/6

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Chd2Gt(RRBO46)Byg/Chd2Gt(RRBO46)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005824 Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...  / complex / reaction
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000017652 Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*  / reaction / complex
 ENSMUSG00000026321 O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000025498 Irf7 / P70434 / interferon regulatory factor 7 / Q92985*  / reaction / complex
 ENSMUSG00000022015 O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / complex / reaction
 ENSMUSG00000031132 Cd40lg / P27548 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P29965* / CD40 ligand*  / complex / reaction
 ENSMUSG00000023905 Q9CR75 / Tnfrsf12a / Tumor necrosis factor receptor superfamily member 12A / Q9NP84* / TNF receptor superfamily member 12A*  / reaction / complex
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex
 ENSMUSG00000024399 Ltb / P41155 / Lymphotoxin-beta / Q06643*  / reaction / complex
 ENSMUSG00000024402 Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*  / complex / reaction
 ENSMUSG00000028599 P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSMUSG00000030339 Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*  / complex / reaction
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / reaction / complex
 ENSMUSG00000056130 Q8BJQ4 / Ticam2 / TIR domain-containing adapter molecule 2 / Q86XR7* / toll like receptor adaptor molecule 2*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / complex / reaction
 ENSMUSG00000051439 Cd14 / P10810 / Monocyte differentiation antigen CD14 / P08571* / CD14 molecule*  / reaction / complex
 ENSMUSG00000047123 Q80UF7 / Ticam1 / TIR domain-containing adapter molecule 1 / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSMUSG00000068105 Q9D8D0 / Tnfrsf13c / tumor necrosis factor receptor superfamily, member 13c / Q96RJ3* / TNF receptor superfamily member 13C*  / complex / reaction
 ENSMUSG00000064289 Tank / P70347 / Mus musculus TRAF family member-associated Nf-kappa B activator (Tank), transcript variant 4, mRNA. / Q92844* / TRAF family member associated NFKB activator*  / reaction / complex
 ENSMUSG00000097328 O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...  / complex / reaction






 

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