ENSMUSG00000017652


Mus musculus

Features
Gene ID: ENSMUSG00000017652
  
Biological name :Cd40
  
Synonyms : Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5
  
Possible biological names infered from orthology : CD40 molecule / P25942
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 165055627
Gene end: 165072948
  
Corresponding Affymetrix probe sets: 10478678 (MoGene1.0st)   1439221_s_at (Mouse Genome 430 2.0 Array)   1449473_s_at (Mouse Genome 430 2.0 Array)   1460415_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139193
Ensembl peptide - ENSMUSP00000122981
Ensembl peptide - ENSMUSP00000138707
Ensembl peptide - ENSMUSP00000017799
Ensembl peptide - ENSMUSP00000073386
Ensembl peptide - ENSMUSP00000080059
NCBI entrez gene - 21939     See in Manteia.
MGI - MGI:88336
RefSeq - XM_017317125
RefSeq - NM_011611
RefSeq - NM_170702
RefSeq - NM_170703
RefSeq - NM_170704
RefSeq - XM_006499154
RefSeq - XM_006499155
RefSeq - XM_017317123
RefSeq Peptide - NP_035741
RefSeq Peptide - NP_733803
RefSeq Peptide - NP_733804
RefSeq Peptide - NP_733805
swissprot - A2A5L7
swissprot - P27512
swissprot - S4R2M8
Ensembl - ENSMUSG00000017652
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd40ENSDARG00000054968Danio rerio
 tnfrsf11aENSDARG00000087804Danio rerio
 CD40ENSGALG00000007015Gallus gallus
 CD40ENSG00000101017Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*ENSMUSG0000002632129
Q9EPU5 / Tnfrsf21 / Tumor necrosis factor receptor superfamily member 21 / O75509* / TNF receptor superfamily member 21*ENSMUSG0000002391525
Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*ENSMUSG0000003033923
Tnfrsf14 / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) / Q92956* / TNF receptor superfamily member 14*ENSMUSG0000004233322
P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*ENSMUSG0000002859921
O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*ENSMUSG0000006372721


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR020435  Tumour necrosis factor receptor 5
 IPR034021  Tumour necrosis factor receptor 5, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IGI
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0033590 response to cobalamin IEA
 biological_processGO:0034341 response to interferon-gamma IEA
 biological_processGO:0036018 cellular response to erythropoietin IEA
 biological_processGO:0042113 B cell activation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein ISO
 biological_processGO:0042832 defense response to protozoan IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity ISO
 biological_processGO:0043491 protein kinase B signaling IDA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IDA
 biological_processGO:0050776 regulation of immune response IDA
 biological_processGO:0051023 regulation of immunoglobulin secretion IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0090037 positive regulation of protein kinase C signaling ISO
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:1901652 response to peptide IEA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043196 varicosity IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003823 antigen binding IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catsper3tm1.1(KOMP)Vlcg/Catsper3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Catsper3tm1.1(KOMP)Vlcg/Ucd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Grin1tm2Slab/Grin1tm1.1Slab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40m2Btlr/Cd40m2Btlr
Genetic Background: C57BL/6J-Cd40m2Btlr

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

Allelic Composition: Cd40m2Btlr/Cd40m2Btlr
Genetic Background: C57BL/6J-Cd40m2Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mkxtm1.1Asah/Mkxtm1.1Asah
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Ltbrtm1Mmat/Ltbrtm1Mmat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix,Tnfsf13btm1Msc/Tnfsf13btm1Msc
Genetic Background: involves: 129 * 129S2/SvPas * BALB/c

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gnat1irdr/Gnat1irdr
Genetic Background: involves: ICR

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
Show

Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005612 decreased susceptibility to type II hypersensitivity reaction "less likelihood of or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005671 response to transplant "the body s reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

 MP:0008179 absent germinal center B cells "absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Traf3ip2tm1.1Lix/Traf3ip2tm1.1Lix
Genetic Background: involves: 129 * 129P2/OlaHsd * BALB/c

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Arah/Cd40tm1Arah
Genetic Background: B6.129S1-Cd40tm1Arah

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008523 absent lymph node germinal center "absence of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Btktm1Wk/Btktm1Wk,Cd40tm1Geha/Cd40tm1Geha
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009544 abnormal thymus epithelium morphology "any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Ltbrtm1Mmat/Ltbrtm1Mmat
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tnfsf11tm1Pngr/Tnfsf11tm1Pngr
Genetic Background: involves: 129P2/OlaHsd

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0010873 decreased trabecular bone mass "reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0010962 decreased compact bone mass 
Show

Allelic Composition: Cxcr4tm1Yzo/Cxcr4tm1Yzo
Genetic Background: Not Specified

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Ccr7m1Btlr/Ccr7+
Genetic Background: C57BL/6J-Ccr7m1Btlr

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Cd40tm1Kik/Cd40tm1Kik,Tg(Tnfsf13b)1Fma/?
Genetic Background: B6.Cg-Cd40tm1Kik Tg(Tnfsf13b)1Fma

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017652 Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*  / complex
 ENSMUSG00000031132 Cd40lg / P27548 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P29965* / CD40 ligand*  / reaction / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr