ENSGALG00000007015


Gallus gallus

Features
Gene ID: ENSGALG00000007015
  
Biological name :CD40
  
Synonyms : CD40 / tumor necrosis factor receptor superfamily member 5 precursor
  
Possible biological names infered from orthology : CD40 molecule / P25942 / P27512 / Tumor necrosis factor receptor superfamily member 5
  
Species: Gallus gallus
  
Chr. number: 20
Strand: 1
Band:
Gene start: 10824114
Gene end: 10827796
  
Corresponding Affymetrix probe sets: Gga.197.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000038316
NCBI entrez gene - 395385     See in Manteia.
RefSeq - NM_204665
RefSeq - XM_015296327
RefSeq Peptide - NP_989996
swissprot - F1NNR7
Ensembl - ENSGALG00000007015
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cd40ENSDARG00000054968Danio rerio
 tnfrsf11aENSDARG00000087804Danio rerio
 CD40ENSG00000101017Homo sapiens
 Cd40ENSMUSG00000017652Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNFRSF11A / TNF receptor superfamily member 11a / O35305* / Q9Y6Q6* / Tumor necrosis factor receptor superfamily member 11A *ENSGALG0000004564227
TNFRSF21 / tumor necrosis factor receptor superfamily member 21 precursor / O75509* / Q9EPU5* / TNF receptor superfamily member 21* / Tumor necrosis factor receptor superfamily member 21 *ENSGALG0000001671921
TNFRSF1B / tumor necrosis factor receptor superfamily member 1B precursor / P20333* / P25119* / TNF receptor superfamily member 1B* / tumor necrosis factor receptor superfamily, member 1b*ENSGALG0000003421320
TNFRSF6B / TNF receptor superfamily member 6b / O95407*ENSGALG0000000610620
TNFRSF11B / tumor necrosis factor receptor superfamily member 11B precursor / O00300* / O08712* / TNF receptor superfamily member 11b* / tumor necrosis factor receptor superfamily, member ...ENSGALG0000004316720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR020435  Tumour necrosis factor receptor 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042832 defense response to protozoan IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048304 positive regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0050776 regulation of immune response IEA
 biological_processGO:0051023 regulation of immunoglobulin secretion IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0090037 positive regulation of protein kinase C signaling IEA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:2000353 positive regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035631 CD40 receptor complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA


Pathways (from Reactome)
Pathway description
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000011389 TRAF3 / TNF receptor associated factor 3 / Q13114* / Q60803*  / reaction / complex
 ENSGALG00000017186 BIRC2 / BIRC3* / Q62210* / Q13489* / Q13490* / baculoviral IAP repeat containing 2* / baculoviral IAP repeat containing 3* / Baculoviral IAP repeat-containing protein 2 *  / complex / reaction
 ENSGALG00000007015 CD40 / tumor necrosis factor receptor superfamily member 5 precursor / P25942* / P27512* / CD40 molecule* / Tumor necrosis factor receptor superfamily member 5 *  / complex
 ENSGALG00000006415 CD40LG / Q9I8D8 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P27548* / P29965* / CD40 ligand*  / reaction / complex






 

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