ENSMUSG00000023915


Mus musculus

Features
Gene ID: ENSMUSG00000023915
  
Biological name :Tnfrsf21
  
Synonyms : Q9EPU5 / Tnfrsf21 / Tumor necrosis factor receptor superfamily member 21
  
Possible biological names infered from orthology : O75509 / TNF receptor superfamily member 21
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 43016555
Gene end: 43089188
  
Corresponding Affymetrix probe sets: 10445241 (MoGene1.0st)   1422740_at (Mouse Genome 430 2.0 Array)   1450731_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024708
NCBI entrez gene - 94185     See in Manteia.
MGI - MGI:2151075
RefSeq - NM_178589
RefSeq Peptide - NP_848704
swissprot - Q9EPU5
Ensembl - ENSMUSG00000023915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfrsf21ENSDARG00000001807Danio rerio
 TNFRSF21ENSGALG00000016719Gallus gallus
 O75509ENSG00000146072Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*ENSMUSG0000006372716
P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*ENSMUSG0000002859915
O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*ENSMUSG0000002632113
Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*ENSMUSG0000003033912
Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*ENSMUSG0000001765211
Tnfrsf14 / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) / Q92956* / TNF receptor superfamily member 14*ENSMUSG000000423339


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR022330  Tumour necrosis factor receptor 21
 IPR034034  Tumor necrosis factor receptor 21, N-terminal
 IPR034037  Tumor necrosis factor receptor 21, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001783 B cell apoptotic process IMP
 biological_processGO:0002250 adaptive immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030889 negative regulation of B cell proliferation IMP
 biological_processGO:0031642 negative regulation of myelination IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0042552 myelination IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0048713 regulation of oligodendrocyte differentiation IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0051402 neuron apoptotic process IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:0097252 oligodendrocyte apoptotic process IMP
 biological_processGO:2000663 negative regulation of interleukin-5 secretion IMP
 biological_processGO:2000666 negative regulation of interleukin-13 secretion IMP
 biological_processGO:2001180 negative regulation of interleukin-10 secretion IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IDA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Tnfrsf21tm2Gne/Tnfrsf21tm2Gne,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

Allelic Composition: Tnfrsf21tm2Gne/Tnfrsf21tm2Gne,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gsdma3Ae/Gsdma3+
Genetic Background: involves: C57BL/6J * CAST/Ei

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb
Genetic Background: involves: BALB/c

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Tnfrsf21tm1Ddy/Tnfrsf21tm1Ddy
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010160 increased oligodendrocyte number "greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS" [MESH:A08.637.600, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nedd4ltm1Shkr/Nedd4ltm1Shkr
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr