ENSG00000146072


Homo sapiens

Features
Gene ID: ENSG00000146072
  
Biological name :TNFRSF21
  
Synonyms : O75509 / TNF receptor superfamily member 21 / TNFRSF21
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p12.3
Gene start: 47231532
Gene end: 47309905
  
Corresponding Affymetrix probe sets: 214581_x_at (Human Genome U133 Plus 2.0 Array)   218856_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000296861
NCBI entrez gene - 27242     See in Manteia.
OMIM - 605732
RefSeq - NM_014452
RefSeq Peptide - NP_055267
swissprot - A0A024RD71
swissprot - O75509
Ensembl - ENSG00000146072
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfrsf21ENSDARG00000001807Danio rerio
 TNFRSF21ENSGALG00000016719Gallus gallus
 Q9EPU5ENSMUSG00000023915Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00300 / TNFRSF11B / TNF receptor superfamily member 11bENSG0000016476116
P20333 / TNFRSF1B / TNF receptor superfamily member 1BENSG0000002813716
Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11aENSG0000014165515
LTBR / P36941 / lymphotoxin beta receptorENSG0000011132112
CD40 / P25942 / CD40 moleculeENSG0000010101711
O95407 / TNFRSF6B / TNF receptor superfamily member 6bENSG0000024350911
Q92956 / TNFRSF14 / TNF receptor superfamily member 14ENSG000001578739


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011029  Death-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR022330  Tumour necrosis factor receptor 21
 IPR034034  Tumor necrosis factor receptor 21, N-terminal
 IPR034037  Tumor necrosis factor receptor 21, death domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001783 B cell apoptotic process ISS
 biological_processGO:0002250 adaptive immune response ISS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0006959 humoral immune response ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030889 negative regulation of B cell proliferation ISS
 biological_processGO:0031642 negative regulation of myelination IMP
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042130 negative regulation of T cell proliferation ISS
 biological_processGO:0042552 myelination ISS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0048713 regulation of oligodendrocyte differentiation IBA
 biological_processGO:0050852 T cell receptor signaling pathway ISS
 biological_processGO:0051402 neuron apoptotic process ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 biological_processGO:0097252 oligodendrocyte apoptotic process ISS
 biological_processGO:2000663 negative regulation of interleukin-5 secretion ISS
 biological_processGO:2000666 negative regulation of interleukin-13 secretion ISS
 biological_processGO:2001180 negative regulation of interleukin-10 secretion ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISS
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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