ENSG00000157873


Homo sapiens

Features
Gene ID: ENSG00000157873
  
Biological name :TNFRSF14
  
Synonyms : Q92956 / TNF receptor superfamily member 14 / TNFRSF14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.32
Gene start: 2555639
Gene end: 2565382
  
Corresponding Affymetrix probe sets: 209354_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000399292
Ensembl peptide - ENSP00000399533
Ensembl peptide - ENSP00000486304
Ensembl peptide - ENSP00000415254
Ensembl peptide - ENSP00000411854
Ensembl peptide - ENSP00000347948
Ensembl peptide - ENSP00000386859
NCBI entrez gene - 8764     See in Manteia.
OMIM - 602746
RefSeq - XM_017002721
RefSeq - NM_001297605
RefSeq - NM_003820
RefSeq - XM_006711019
RefSeq - XM_017002720
RefSeq Peptide - NP_001284534
RefSeq Peptide - NP_003811
swissprot - A0A0D9SF52
swissprot - A0A024R052
swissprot - F6Q0M4
swissprot - Q92956
swissprot - F6UPZ7
swissprot - B9A034
Ensembl - ENSG00000157873
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CT737125.1ENSDARG00000068991Danio rerio
 si:ch211-261n11.7ENSDARG00000068966Danio rerio
 si:ch211-261n11.8ENSDARG00000089901Danio rerio
 si:dkey-23c22.5ENSDARG00000092892Danio rerio
 si:dkey-23c22.7ENSDARG00000095193Danio rerio
 zgc:153631ENSDARG00000068993Danio rerio
 zgc:153759ENSDARG00000092381Danio rerio
 zgc:153759ENSDARG00000068969Danio rerio
 Tnfrsf14ENSMUSG00000042333Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P20333 / TNFRSF1B / TNF receptor superfamily member 1BENSG0000002813724
CD40 / P25942 / CD40 moleculeENSG0000010101722
Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11aENSG0000014165522
O95407 / TNFRSF6B / TNF receptor superfamily member 6bENSG0000024350922
LTBR / P36941 / lymphotoxin beta receptorENSG0000011132121
O75509 / TNFRSF21 / TNF receptor superfamily member 21ENSG0000014607221
O00300 / TNFRSF11B / TNF receptor superfamily member 11bENSG0000016476120


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR022332  Tumour necrosis factor receptor 14
 IPR034031  Tumor necrosis factor receptor 14/UL144, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI


Pathways (from Reactome)
Pathway description
Costimulation by the CD28 family
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000186265 BTLA / Q7Z6A9 / B and T lymphocyte associated  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction / complex
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction






 

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