ENSG00000243509


Homo sapiens

Features
Gene ID: ENSG00000243509
  
Biological name :TNFRSF6B
  
Synonyms : O95407 / TNF receptor superfamily member 6b / TNFRSF6B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.33
Gene start: 63696651
Gene end: 63698684
  
Corresponding Affymetrix probe sets: 206467_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359013
NCBI entrez gene - 8771     See in Manteia.
OMIM - 603361
RefSeq - NM_003823
RefSeq Peptide - NP_003814
swissprot - O95407
Ensembl - ENSG00000243509
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfrsf11bENSDARG00000098377Danio rerio
 TNFRSF6BENSGALG00000006106Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O00300 / TNFRSF11B / TNF receptor superfamily member 11bENSG0000016476132
O75509 / TNFRSF21 / TNF receptor superfamily member 21ENSG0000014607225
P20333 / TNFRSF1B / TNF receptor superfamily member 1BENSG0000002813724
LTBR / P36941 / lymphotoxin beta receptorENSG0000011132122
Q92956 / TNFRSF14 / TNF receptor superfamily member 14ENSG0000015787321
Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11aENSG0000014165520
CD40 / P25942 / CD40 moleculeENSG0000010101717


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR034023  Tumor necrosis factor receptor 6B, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:0097190 apoptotic signaling pathway IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space NAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000117560 FASLG / P48023 / Fas ligand  / complex / reaction
 ENSG00000181634 O95150 / TNFSF15 / TNF superfamily member 15  / reaction / complex






 

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