ENSG00000125735


Homo sapiens

Features
Gene ID: ENSG00000125735
  
Biological name :TNFSF14
  
Synonyms : O43557 / TNFSF14 / TNF superfamily member 14
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 6661253
Gene end: 6670588
  
Corresponding Affymetrix probe sets: 207907_at (Human Genome U133 Plus 2.0 Array)   233935_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000245912
Ensembl peptide - ENSP00000469049
NCBI entrez gene - 8740     See in Manteia.
OMIM - 604520
RefSeq - XM_017027418
RefSeq - NM_003807
RefSeq - NM_172014
RefSeq - XM_017027417
RefSeq Peptide - NP_003798
RefSeq Peptide - NP_742011
swissprot - O43557
Ensembl - ENSG00000125735
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9QYH9ENSMUSG00000005824Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O95150 / TNFSF15 / TNF superfamily member 15ENSG0000018163428
FASLG / P48023 / Fas ligandENSG0000011756024
TNF / P01375 / tumor necrosis factorENSG0000023281022
LTA / P01374 / lymphotoxin alphaENSG0000022697920


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042098 T cell proliferation NAS
 biological_processGO:0042110 T cell activation NAS
 biological_processGO:0043029 T cell homeostasis NAS
 biological_processGO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045663 positive regulation of myoblast differentiation IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000243509 O95407 / TNFRSF6B / TNF receptor superfamily member 6b  / complex / reaction
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex






 

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