ENSG00000226979


Homo sapiens

Features
Gene ID: ENSG00000226979
  
Biological name :LTA
  
Synonyms : LTA / lymphotoxin alpha / P01374
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.33
Gene start: 31572054
Gene end: 31574324
  
Corresponding Affymetrix probe sets: 206975_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403495
Ensembl peptide - ENSP00000413450
NCBI entrez gene - 4049     See in Manteia.
OMIM - 153440
RefSeq - XM_011514618
RefSeq - NM_000595
RefSeq - NM_001159740
RefSeq - XM_011514616
RefSeq - XM_011514617
RefSeq - XM_011514615
swissprot - Q5STV3
swissprot - P01374
Ensembl - ENSG00000226979
  
Related genetic diseases (OMIM): 607507 - {Psoriatic arthritis, susceptibility to}, 607507
  608446 - {Myocardial infarction, susceptibility to}, 608446
  610988 - {Leprosy, susceptibility to, 4}, 610988
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaENSDARG00000009511Danio rerio
 tnfbENSDARG00000013598Danio rerio
 LtaENSMUSG00000024402Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNF / P01375 / tumor necrosis factorENSG0000023281030
O95150 / TNFSF15 / TNF superfamily member 15ENSG0000018163428
FASLG / P48023 / Fas ligandENSG0000011756025
O43557 / TNFSF14 / TNF superfamily member 14ENSG0000012573524


Protein motifs (from Interpro)
Interpro ID Name
 IPR002960  Lymphotoxin-alpha
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus IEA
 biological_processGO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0048535 lymph node development IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNFs bind their physiological receptors
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / complex / reaction
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000157873 Q92956 / TNFRSF14 / TNF receptor superfamily member 14  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / complex






 

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