ENSG00000227507


Homo sapiens

Features
Gene ID: ENSG00000227507
  
Biological name :LTB
  
Synonyms : LTB / lymphotoxin beta / Q06643
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 31580525
Gene end: 31582522
  
Corresponding Affymetrix probe sets: 1559754_at (Human Genome U133 Plus 2.0 Array)   207339_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410481
Ensembl peptide - ENSP00000416113
NCBI entrez gene - 4050     See in Manteia.
OMIM - 600978
RefSeq - NM_009588
RefSeq - NM_002341
RefSeq Peptide - NP_002332
RefSeq Peptide - NP_033666
swissprot - Q06643
swissprot - Q5STB2
Ensembl - ENSG00000227507
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LtbENSMUSG00000024399Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002961  Lymphotoxin-beta
 IPR006052  Tumour necrosis factor domain
 IPR006053  Tumour necrosis factor
 IPR008983  Tumour necrosis factor-like domain superfamily
 IPR021184  Tumour necrosis factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0010467 gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process ISS
 biological_processGO:0048535 lymph node development IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / complex / reaction
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / reaction / complex
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / reaction / complex
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / complex / reaction
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / complex
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / complex






 

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