ENSG00000023445


Homo sapiens

Features
Gene ID: ENSG00000023445
  
Biological name :BIRC3
  
Synonyms : baculoviral IAP repeat containing 3 / BIRC3 / Q13489
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q22.2
Gene start: 102317450
Gene end: 102339403
  
Corresponding Affymetrix probe sets: 210538_s_at (Human Genome U133 Plus 2.0 Array)   230499_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263464
Ensembl peptide - ENSP00000431718
Ensembl peptide - ENSP00000432907
Ensembl peptide - ENSP00000481903
NCBI entrez gene - 330     See in Manteia.
OMIM - 601721
RefSeq - XM_017017643
RefSeq - NM_001165
RefSeq - NM_182962
RefSeq Peptide - NP_001156
RefSeq Peptide - NP_892007
swissprot - Q13489
swissprot - H0YCJ5
Ensembl - ENSG00000023445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 birc2ENSDARG00000044619Danio rerio
 BIRC2ENSGALG00000017186Gallus gallus
 Birc3ENSMUSG00000032000Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BIRC2 / Q13490 / baculoviral IAP repeat containing 2ENSG0000011033073
XIAP / P98170 / X-linked inhibitor of apoptosisENSG0000010196632
NAIP / Q13075 / NLR family apoptosis inhibitory proteinENSG0000024943722
BIRC7 / Q96CA5 / baculoviral IAP repeat containing 7ENSG0000010119718
BIRC8 / Q96P09 / baculoviral IAP repeat containing 8ENSG0000016309816
NLRC4 / Q9NPP4 / NLR family CARD domain containing 4ENSG0000009110610


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001370  BIR repeat
 IPR001841  Zinc finger, RING-type
 IPR011029  Death-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002756 MyD88-independent toll-like receptor signaling pathway TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0034121 regulation of toll-like receptor signaling pathway TAS
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0038061 NIK/NF-kappaB signaling TAS
 biological_processGO:0039535 regulation of RIG-I signaling pathway TAS
 biological_processGO:0042981 regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0045088 regulation of innate immune response TAS
 biological_processGO:0050727 regulation of inflammatory response TAS
 biological_processGO:0051291 protein heterooligomerization IEA
 biological_processGO:0060544 regulation of necroptotic process TAS
 biological_processGO:0060546 negative regulation of necroptotic process IBA
 biological_processGO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process IBA
 biological_processGO:2000116 regulation of cysteine-type endopeptidase activity TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity EXP
 molecular_functionGO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000505 Impaired vision 
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 HP:0000614 Abnormality of the lacrimal duct 
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 HP:0000820 Abnormality of the thyroid gland 
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 HP:0000975 Hyperhidrosis "An abnormally increased perspiration." [HPO:probinson]
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 HP:0001824 Weight loss 
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 HP:0001903 Anemia 
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 HP:0001945 Fever 
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 HP:0002017 Nausea and vomiting 
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 HP:0002019 Constipation 
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 HP:0002027 Abdominal pain 
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 HP:0002113 Pulmonary infiltrates 
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 HP:0002205 Recurrent respiratory infections 
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 HP:0012123 Posterior uveitis "Inflammation of the uveal tract in which the primary site of inflammation is the retina or choroid." [HPO:probinson]
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 HP:0012191 B-cell lymphoma "A type of lymphoma that originates in B-cells." [HPO:probinson]
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 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
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 HP:0100721 Mediastinal lymphadenopathy 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000131508 P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2  / complex
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / complex / reaction
 ENSG00000067182 P19438 / TNFRSF1A / TNF receptor superfamily member 1A  / complex / reaction
 ENSG00000141655 Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11a  / complex / reaction
 ENSG00000102871 TRADD / Q15628 / TNFRSF1A associated via death domain  / complex / reaction
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000120659 O14788 / TNFSF11 / TNF superfamily member 11  / complex / reaction
 ENSG00000172046 USP19 / O94966 / ubiquitin specific peptidase 19  / complex / reaction
 ENSG00000102245 CD40LG / P29965 / CD40 ligand  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000101017 CD40 / P25942 / CD40 molecule  / reaction / complex
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000232810 TNF / P01375 / tumor necrosis factor  / reaction / complex
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / reaction / complex
 ENSG00000137275 RIPK1 / Q13546 / receptor interacting serine/threonine kinase 1  / reaction / complex
 ENSG00000159958 Q96RJ3 / TNFRSF13C / TNF receptor superfamily member 13C  / reaction / complex
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / reaction / complex
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / reaction / complex
 ENSG00000109332 P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3  / complex
 ENSG00000072401 P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1  / complex
 ENSG00000102524 Q9Y275 / TNFSF13B / TNF superfamily member 13b  / reaction / complex
 ENSG00000028137 P20333 / TNFRSF1B / TNF receptor superfamily member 1B  / complex / reaction






 

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