ENSG00000239697


Homo sapiens

Features
Gene ID: ENSG00000239697
  
Biological name :TNFSF12
  
Synonyms : O43508 / TNFSF12 / TNF superfamily member 12
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 7548891
Gene end: 7557890
  
Corresponding Affymetrix probe sets: 205611_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000293825
Ensembl peptide - ENSP00000314636
NCBI entrez gene - 8742     See in Manteia.
OMIM - 602695
RefSeq - NM_003809
RefSeq Peptide - NP_003800
swissprot - C0H5Y4
swissprot - O43508
swissprot - Q4ACW9
Ensembl - ENSG00000239697
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf13ENSDARG00000091556Danio rerio
 O54907ENSMUSG00000097328Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNFSF12-TNFSF13 / TNFSF12-TNFSF13 readthroughENSG0000024887173
Q9Y275 / TNFSF13B / TNF superfamily member 13bENSG0000010252415
O75888 / TNFSF13 / TNF superfamily member 13ENSG0000016195513


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation TAS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0043542 endothelial cell migration TAS
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0045766 positive regulation of angiogenesis TAS
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000248 Brachycephaly "Brachycephaly refers to a short, wide head, which is often caused by premature closure of both coronal sutures." [HPO:curators]
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 HP:0000389 Chronic otitis media 
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 HP:0000979 Purpura 
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 HP:0001531 Failure to thrive in infancy 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001878 Hemolytic anemia 
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 HP:0001888 Lymphopenia 
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 HP:0001973 Immune thrombocytopenia 
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 HP:0002023 Anal atresia "Congenital absence of the anus, i.e., the opening at the bottom end of the intestinal tract." [HPO:curators]
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 HP:0002090 Pneumonia 
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 HP:0002091 Restrictive lung disease 
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 HP:0002097 Emphysema 
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 HP:0002110 Bronchiectasis 
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 HP:0002633 Vasculitis 
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 HP:0002665 Lymphoma "A cancer originating in lymphocytes and presenting as a solid tumor of lymhpoid cells." [HPO:curators]
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 HP:0002716 Lymphadenopathy 
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 HP:0002721 Immunodeficiency 
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 HP:0002829 Arthralgia 
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 HP:0002837 Bronchitis 
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 HP:0002910 Elevated transaminases "Elevations of the levels of SGOT and SGPT in the serum. SGOT (serum glutamic oxaloacetic transaminase) and SGPT (serum glutamic pyruvic transaminase) are transaminases primarily found in the liver and heart and are released into the bloodstream as the result of liver or heart damage. SGOT and SGPT are used clinically mainly as markers of liver damage." [HPO:curators]
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 HP:0004313 Reduced immunoglobulin levels 
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 HP:0006783 Posterior pharyngeal cleft 
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 HP:0100723 Gastrointestinal stroma tumor 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000006327 Q9NP84 / TNFRSF12A / TNF receptor superfamily member 12A  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000239697 O43508 / TNFSF12 / TNF superfamily member 12  / complex
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / reaction / complex
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex






 

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