ENSMUSG00000097328


Mus musculus

Features
Gene ID: ENSMUSG00000097328
  
Biological name :Tnfsf12
  
Synonyms : O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, secreted form
  
Possible biological names infered from orthology : O43508 / TNF superfamily member 12
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69686250
Gene end: 69695849
  
Corresponding Affymetrix probe sets: 10387568 (MoGene1.0st)   1452440_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137916
Ensembl peptide - ENSMUSP00000137972
NCBI entrez gene - 21944     See in Manteia.
MGI - MGI:1196259
RefSeq - NM_011614
RefSeq Peptide - NP_035744
swissprot - M9MMK6
swissprot - O54907
swissprot - Q5F2A0
Ensembl - ENSMUSG00000097328
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfsf13ENSDARG00000091556Danio rerio
 O43508ENSG00000239697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnfsfm13 / tumor necrosis factor (ligand) superfamily, membrane-bound member 13 / TNFSF12-TNFSF13* / TNFSF12-TNFSF13 readthrough*ENSMUSG0000001875274
Tnfsf13 / tumor necrosis factor (ligand) superfamily, member 13 / O75888* / TNF superfamily member 13*ENSMUSG0000008966914
Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*ENSMUSG0000003149713


Protein motifs (from Interpro)
Interpro ID Name
 IPR006052  Tumour necrosis factor domain
 IPR008983  Tumour necrosis factor-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045732 positive regulation of protein catabolic process IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005164 tumor necrosis factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

 MP:0008663 increased interleukin-12 secretion "increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Tgfbr1tm1Spo/Tgfbr1tm1Spo
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129 * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex
 ENSMUSG00000097328 O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...  / complex
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / reaction / complex
 ENSMUSG00000023905 Q9CR75 / Tnfrsf12a / Tumor necrosis factor receptor superfamily member 12A / Q9NP84* / TNF receptor superfamily member 12A*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction






 

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