ENSMUSG00000023905


Mus musculus

Features
Gene ID: ENSMUSG00000023905
  
Biological name :Tnfrsf12a
  
Synonyms : Q9CR75 / Tnfrsf12a / Tumor necrosis factor receptor superfamily member 12A
  
Possible biological names infered from orthology : Q9NP84 / TNF receptor superfamily member 12A
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 23675447
Gene end: 23677449
  
Corresponding Affymetrix probe sets: 10448307 (MoGene1.0st)   1418571_at (Mouse Genome 430 2.0 Array)   1418572_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024698
Ensembl peptide - ENSMUSP00000131574
NCBI entrez gene - 27279     See in Manteia.
MGI - MGI:1351484
RefSeq - NM_001161746
RefSeq - NM_013749
RefSeq Peptide - NP_001155218
RefSeq Peptide - NP_038777
swissprot - Q9CR75
swissprot - E9PZT5
Ensembl - ENSMUSG00000023905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q9NP84ENSG00000006327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022316  Tumour necrosis factor receptor 12


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006931 substrate-dependent cell migration, cell attachment to substrate IDA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045765 regulation of angiogenesis IDA
 biological_processGO:0045773 positive regulation of axon extension IDA
 biological_processGO:0061041 regulation of wound healing IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Fmr1tm1Cidz/Fmr1tm1Cidz,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010042 abnormal oval cell physiology "any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes" [PMID:16237666]
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Allelic Composition: Fmr1tm1Cidz/Fmr1tm1Cidz,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000023905 Q9CR75 / Tnfrsf12a / Tumor necrosis factor receptor superfamily member 12A / Q9NP84* / TNF receptor superfamily member 12A*  / reaction / complex
 ENSMUSG00000097328 O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...  / complex / reaction






 

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