ENSMUSG00000020941


Mus musculus

Features
Gene ID: ENSMUSG00000020941
  
Biological name :Map3k14
  
Synonyms : Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q9WUL6
  
Possible biological names infered from orthology : Q99558
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E1
Gene start: 103219762
Gene end: 103267472
  
Corresponding Affymetrix probe sets: 10391870 (MoGene1.0st)   1422999_at (Mouse Genome 430 2.0 Array)   1434364_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021324
NCBI entrez gene - 53859     See in Manteia.
MGI - MGI:1858204
RefSeq - NM_016896
RefSeq Peptide - NP_058592
swissprot - Q544K4
swissprot - Q9WUL6
Ensembl - ENSMUSG00000020941
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arf2bENSDARG00000056582Danio rerio
 map3k14aENSDARG00000074060Danio rerio
 MAP3K14ENSGALG00000000685Gallus gallus
 Q99558ENSG00000006062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q3S4 / Map3k19 / Mitogen-activated protein kinase kinase kinase 19 / Q56UN5*ENSMUSG0000005159014
Map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSMUSG0000002438314
Map3k1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*ENSMUSG0000002175414
Map3k3 / Q61084 / Mitogen-activated protein kinase kinase kinase 3 / Q99759*ENSMUSG0000002070013
Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*ENSMUSG0000002423511


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017425  Mitogen-activated protein (MAP) kinase kinase kinase 14
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IDA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0038061 NIK/NF-kappaB signaling IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISO
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004704 NF-kappaB-inducing kinase activity IDA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000705 athymia "absence of the primary lymphoid organ" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1nu/Foxn1nu,Map3k14aly/Map3k14aly
Genetic Background: involves: BALB/cAJcl * C57BL/6J

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: involves: C57BL/6J

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a16H/ae
Genetic Background: involves: 101/H * C3H/HeH * P * S

 MP:0002138 abnormal liver/biliary system morphology "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbk1tm1Arte/Tbk1tm1Arte,Map3k14tm1Rds/Map3k14tm1Rds,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129/SvEv * 129P2/OlaHsd * C57BL/6

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0002375 abnormal thymus medulla morphology "anomalous structure or development of the inner area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: a16H/ae
Genetic Background: involves: 101/H * C3H/HeH * P * S

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Map3k14tm1Rds/Map3k14tm1Rds
Genetic Background: involves: 129/Sv

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

Allelic Composition: Foxn1nu/Foxn1nu,Map3k14aly/Map3k14aly
Genetic Background: involves: BALB/cAJcl * C57BL/6J

Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0003253 bile duct dilation "abnormal distention of the bile ducts due to accumulation of fluid or bile" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0003254 bile duct inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0003255 bile duct proliferation "the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Map3k14tm1Rds/Map3k14tm1Rds
Genetic Background: involves: 129/Sv

 MP:0004839 bile duct hyperplasia "overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: FtoI367F/Fto+
Genetic Background: involves: C3H/HeH * C57BL/6J

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxn1nu/Foxn1nu,Map3k14aly/Map3k14aly
Genetic Background: involves: BALB/cAJcl * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hcrttm1Ywa/Hcrt+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: C57BL/6J-Map3k14aly

Allelic Composition: Foxn1nu/Foxn1nu,Map3k14aly/Map3k14aly
Genetic Background: involves: BALB/cAJcl * C57BL/6J

 MP:0008036 abnormal NK T cell morphology "any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

Allelic Composition: Map3k14aly/Map3k14+,RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008071 absent B cells "absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1nu/Foxn1nu,Map3k14aly/Map3k14aly
Genetic Background: involves: BALB/cAJcl * C57BL/6J

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Map3k14aly/Map3k14+,RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic Background: involves: C57BL/6 * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Map3k14aly/Map3k14+,RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14m1Btlr/Map3k14m1Btlr
Genetic Background: C57BL/6J-Map3k14m1Btlr

 MP:0008234 absent spleen marginal zone "absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
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Allelic Composition: Foxn1nu/Foxn1nu,Map3k14aly/Map3k14aly
Genetic Background: involves: BALB/cAJcl * C57BL/6J

 MP:0008397 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology "any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0008465 absent mesenteric lymph nodes "absence of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+,Map3k14tm1.1Gne/Map3k14tm1.1Gne
Genetic Background: B6(Cg)-Map3k14tm1.1Gne Gt(ROSA)26Sortm9(cre/ESR1)Arte

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

Allelic Composition: Map3k14aly/Map3k14+,RelbTg(H2-K1/GH1)106Bri/Relb+
Genetic Background: involves: C57BL/6 * C57BL/6J

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0008880 lacrimal gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0008904 abnormal mammary fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0009297 decreased mammary fat pad weight 
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0009543 abnormal thymus corticomedullary boundary morphology "any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0009629 small brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009632 small axillary lymph nodes "reduced size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009634 absent popliteal lymph nodes "absence of the lymph nodes which drain the legs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0009923 decreased transitional stage T1 B cell number "reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative" [PMID:12810111]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0009926 decreased transitional stage T2 B cell number "reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles" [PMID:12810111]
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Allelic Composition: Map3k14tm1.2Gne/Map3k14tm1.2Gne
Genetic Background: B6(Cg)-Map3k14tm1.2Gne

 MP:0013741 absent thymus corticomedullary boundary " complete absence or loss of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; normally, this is the site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:Anna, PMID:17067941]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: AEJ/GnRk * C57BL/6J

 MP:0014130 thymus cysts "presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]
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Allelic Composition: Map3k14aly/Map3k14aly
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005824 Q9QYH9 / Tnfsf14 / Tumor necrosis factor ligand superfamily member 14 Tumor necrosis factor ligand superfamily member 14, membrane form Tumor necrosis factor ligand superfamily member 14, so...  / complex / reaction
 ENSMUSG00000023905 Q9CR75 / Tnfrsf12a / Tumor necrosis factor receptor superfamily member 12A / Q9NP84* / TNF receptor superfamily member 12A*  / reaction / complex
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / complex / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000026321 O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*  / complex / reaction
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction / complex
 ENSMUSG00000031132 Cd40lg / P27548 / CD40 ligand CD40 ligand, membrane form CD40 ligand, soluble form / P29965* / CD40 ligand*  / reaction / complex
 ENSMUSG00000022015 O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*  / complex / reaction
 ENSMUSG00000017652 Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*  / complex / reaction
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / complex / reaction
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / reaction
 ENSMUSG00000024399 Ltb / P41155 / Lymphotoxin-beta / Q06643*  / reaction / complex
 ENSMUSG00000024402 Lta / P09225 / lymphotoxin A / P01374* / lymphotoxin alpha*  / reaction / complex
 ENSMUSG00000028599 P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*  / complex / reaction
 ENSMUSG00000030339 Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*  / reaction / complex
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / complex / reaction
 ENSMUSG00000002983 Relb / Q04863 / avian reticuloendotheliosis viral (v-rel) oncogene related B / Q01201* / RELB proto-oncogene, NF-kB subunit*  / complex / reaction
 ENSMUSG00000068105 Q9D8D0 / Tnfrsf13c / tumor necrosis factor receptor superfamily, member 13c / Q96RJ3* / TNF receptor superfamily member 13C*  / complex / reaction
 ENSMUSG00000025225 Nfkb2 / Q9WTK5 / nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100 / Q00653* / nuclear factor kappa B subunit 2*  / complex / reaction
 ENSMUSG00000097328 O54907 / Tnfsf12 / Tumor necrosis factor ligand superfamily member 12 Tumor necrosis factor ligand superfamily member 12, membrane form Tumor necrosis factor ligand superfamily member 12, se...  / complex / reaction






 

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