ENSDARG00000056582


Danio rerio

Features
Gene ID: ENSDARG00000056582
  
Biological name :map3k14b
  
Synonyms : arf2b / map3k14b / mitogen-activated protein kinase kinase kinase 14b
  
Possible biological names infered from orthology : MAP3K14 / mitogen-activated protein kinase kinase kinase 14 / Q99558 / Q9WUL6
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 36373588
Gene end: 36400458
  
Corresponding Affymetrix probe sets: Dr.5438.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000073556
Ensembl peptide - ENSDARP00000150631
NCBI entrez gene - 327026     See in Manteia.
swissprot - F1QV75
ZFIN ID - ZDB-GENE-030131-5234
ZFIN ID - ZDB-GENE-091204-121
Ensembl - ENSDARG00000056582
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K14ENSGALG00000000685Gallus gallus
 Q99558ENSG00000006062Homo sapiens
 Q9WUL6ENSMUSG00000020941Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*ENSDARG0000007406034
map3k1 / mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase / Q13233* / mitogen-activated protein kinase kinase kinase 1*ENSDARG0000009840511
map3k8 / mitogen-activated protein kinase kinase kinase 8 / P41279* / Q07174*ENSDARG0000006171011
map3k3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*ENSDARG0000006034811
map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSDARG0000006288410
map3k19 / mitogen-activated protein kinase kinase kinase 19 / E9Q3S4* / Q56UN5*ENSDARG000000942728
map3k20 / mitogen-activated protein kinase kinase kinase 20ENSDARG000000742191


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017425  Mitogen-activated protein (MAP) kinase kinase kinase 14
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
Dectin-1 mediated noncanonical NF-kB signaling
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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