ENSDARG00000061710


Danio rerio

Features
Gene ID: ENSDARG00000061710
  
Biological name :map3k8
  
Synonyms : map3k8 / mitogen-activated protein kinase kinase kinase 8
  
Possible biological names infered from orthology : P41279 / Q07174
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 23647546
Gene end: 23658888
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000082752
NCBI entrez gene - 563727     See in Manteia.
swissprot - E7F4L2
ZFIN ID - ZDB-GENE-100316-8
Ensembl - ENSDARG00000061710
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MAP3K8ENSGALG00000007356Gallus gallus
 MAP3K8ENSG00000107968Homo sapiens
 Map3k8ENSMUSG00000024235Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*ENSDARG0000007406021
map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSDARG0000006288421
map3k3 / mitogen-activated protein kinase kinase kinase 3 / Q61084* / Q99759*ENSDARG0000006034821
arf2b / map3k14b / mitogen-activated protein kinase kinase kinase 14b / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*ENSDARG0000005658219
map3k1 / mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase / Q13233* / mitogen-activated protein kinase kinase kinase 1*ENSDARG0000009840519
map3k19 / mitogen-activated protein kinase kinase kinase 19 / E9Q3S4* / Q56UN5*ENSDARG0000009427217
map3k20 / mitogen-activated protein kinase kinase kinase 20ENSDARG000000742193


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000074501 tnip2 / TNFAIP3 interacting protein 2 / Q8NFZ5* / Q99JG7*  / reaction / complex
 ENSDARG00000003151 skp1 / S-phase kinase-associated protein 1 / Skp1a* / P63208* / Q9WTX5* / AC104109.3* / S-phase kinase-associated protein 1A*  / reaction / complex
 ENSDARG00000104806 fbxw11a / F-box and WD repeat domain containing 11a / FBXW11* / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000019239 cul1a / cullin 1a / CUL1* / Q13616* / Q9WTX6* / cullin 1* / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA.*  / complex / reaction
 ENSDARG00000074060 map3k14a / mitogen-activated protein kinase kinase kinase 14a / Q9WUL6* / Q99558* / MAP3K14* / mitogen-activated protein kinase kinase kinase 14*  / reaction
 ENSDARG00000017230 fbxw11b / F-box and WD repeat domain containing 11b / Q9UKB1* / FBXW11* / Q5SRY7* / F-box/WD repeat-containing protein 11 * / F-box and WD repeat domain containing 11*  / complex / reaction
 ENSDARG00000105261 nfkb1 / nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 / P25799* / P19838* / nuclear factor kappa B subunit 1* / Nuclear factor NF-kappa-B p105 subunit Nuclear factor ...  / reaction / complex
 ENSDARG00000079123 ikbkb / inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta / O14920* / inhibitor of kappaB kinase beta* / inhibitor of nuclear factor kappa B kinase subunit beta*  / reaction






 

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