ENSMUSG00000024235


Mus musculus

Features
Gene ID: ENSMUSG00000024235
  
Biological name :Map3k8
  
Synonyms : Map3k8 / mitogen-activated protein kinase kinase kinase 8 / Q07174
  
Possible biological names infered from orthology : P41279
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: A1
Gene start: 4331327
Gene end: 4353015
  
Corresponding Affymetrix probe sets: 10457225 (MoGene1.0st)   1419208_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025078
Ensembl peptide - ENSMUSP00000133469
NCBI entrez gene - 26410     See in Manteia.
MGI - MGI:1346878
RefSeq - XM_006525944
RefSeq - NM_007746
RefSeq - XM_006525943
RefSeq Peptide - NP_031772
swissprot - Q07174
swissprot - Q3UEB8
swissprot - G3UWY2
Ensembl - ENSMUSG00000024235
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k8ENSDARG00000061710Danio rerio
 MAP3K8ENSGALG00000007356Gallus gallus
 MAP3K8ENSG00000107968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Map3k3 / Q61084 / Mitogen-activated protein kinase kinase kinase 3 / Q99759*ENSMUSG0000002070023
Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*ENSMUSG0000002094123
Map3k2 / mitogen-activated protein kinase kinase kinase 2 / Q9Y2U5*ENSMUSG0000002438322
E9Q3S4 / Map3k19 / Mitogen-activated protein kinase kinase kinase 19 / Q56UN5*ENSMUSG0000005159022
Map3k1 / mitogen-activated protein kinase kinase kinase 1 / Q13233*ENSMUSG0000002175419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017424  Mitogen-activated protein (MAP) kinase kinase kinase 8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
CD28 dependent PI3K/Akt signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Izumo1rtm2a(KOMP)Wtsi/Izumo1rtm2a(KOMP)Wtsi
Genetic Background: C57BL/6N-Izumo1rtm2a(KOMP)Wtsi/Wtsi

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k8M1Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M1Btlr

Allelic Composition: Map3k8m2Btlr/Map3k8m2Btlr
Genetic Background: C57BL/6J-Map3k8m2Btlr

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Map3k8M1Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Tnftm2Gkl/Tnf+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008556 abnormal tumor necrosis factor secretion "anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Trpm4tm1.1Knt/Trpm4tm1.1Knt,Trpm5tm1Csz/Trpm5tm1Csz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Map3k8M1Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M1Btlr

Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Map3k8tm1Sley/Map3k8tm1Sley,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

Allelic Composition: Map3k8m3Btlr/Map3k8m3Btlr
Genetic Background: C57BL/6J-Map3k8m3Btlr

Allelic Composition: Map3k8m3Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8m3Btlr

Allelic Composition: Map3k8M4Btlr/Map3k8M4Btlr
Genetic Background: C57BL/6J-Map3k8M4Btlr

Allelic Composition: Map3k8M4Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M4Btlr

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0008669 increased interleukin-12b secretion "increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Map3k8tm1Pnt/Map3k8tm1Pnt,Nfkb1tm1Sley/Nfkb1tm1Sley
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0008884 abnormal enterocyte apoptosis "change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3atm1a(EUCOMM)Wtsi/Gsk3a+,Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

 MP:0011079 decreased macrophage cytokine production "reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k8m3Btlr/Map3k8m3Btlr
Genetic Background: C57BL/6J-Map3k8m3Btlr

Allelic Composition: Map3k8m3Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8m3Btlr

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Map3k8M1Btlr/Map3k8+
Genetic Background: C57BL/6J-Map3k8M1Btlr

Allelic Composition: Map3k8M1Btlr/Map3k8M1Btlr
Genetic Background: C57BL/6J-Map3k8M1Btlr

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Map3k8tm1.2Gkl/Map3k8tm1.2Gkl
Genetic Background: involves: 129 * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / reaction / complex
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / reaction
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / complex / reaction
 ENSMUSG00000059866 Tnip2 / Q99JG7 / TNFAIP3 interacting protein 2 / Q8NFZ5*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / reaction / complex
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / complex / reaction






 

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