ENSMUSG00000059866


Mus musculus

Features
Gene ID: ENSMUSG00000059866
  
Biological name :Tnip2
  
Synonyms : Q99JG7 / TNFAIP3 interacting protein 2 / Tnip2
  
Possible biological names infered from orthology : Q8NFZ5
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: B2
Gene start: 34496087
Gene end: 34513991
  
Corresponding Affymetrix probe sets: 10529402 (MoGene1.0st)   1419488_at (Mouse Genome 430 2.0 Array)   1459844_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109999
Ensembl peptide - ENSMUSP00000030991
Ensembl peptide - ENSMUSP00000085030
NCBI entrez gene - 231130     See in Manteia.
MGI - MGI:2386643
RefSeq - NM_139064
RefSeq Peptide - NP_620703
swissprot - D3Z039
swissprot - Q80VZ7
swissprot - Q99JG7
Ensembl - ENSMUSG00000059866
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnip2ENSDARG00000074501Danio rerio
 TNIP2ENSGALG00000015666Gallus gallus
 TNIP2ENSG00000168884Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022008  TSG101 and ALIX binding domain of CEP55
 IPR024042  TM1646-like domain superfamily
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR034735  NEMO, Zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0023035 CD40 signaling pathway IMP
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IMP
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IMP
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0050871 positive regulation of B cell activation IMP
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Brca1tm1Aash/Brca1tm1Aash,Tg(LGB-cre)74Acl/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024235 Map3k8 / Q07174 / mitogen-activated protein kinase kinase kinase 8 / P41279*  / reaction / complex
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / complex / reaction
 ENSMUSG00000020271 Fbxw11 / Q5SRY7 / F-box/WD repeat-containing protein 11 / Q9UKB1* / F-box and WD repeat domain containing 11*  / reaction / complex
 ENSMUSG00000036309 Skp1a / Q9WTX5 / S-phase kinase-associated protein 1A / SKP1* / P63208* / AC104109.3* / S-phase kinase associated protein 1*  / complex / reaction
 ENSMUSG00000029686 Cul1 / Q9WTX6 / Mus musculus cullin 1 (Cul1), transcript variant 3, mRNA. / Q13616* / cullin 1*  / reaction / complex
 ENSMUSG00000025217 Btrc / Q3ULA2 / F-box/WD repeat-containing protein 1A / Q9Y297* / beta-transducin repeat containing E3 ubiquitin protein ligase*  / reaction / complex
 ENSMUSG00000028163 Nfkb1 / P25799 / Nuclear factor NF-kappa-B p105 subunit Nuclear factor NF-kappa-B p50 subunit / P19838* / nuclear factor kappa B subunit 1*  / complex / reaction






 

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