ENSMUSG00000019850


Mus musculus

Features
Gene ID: ENSMUSG00000019850
  
Biological name :Tnfaip3
  
Synonyms : Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3
  
Possible biological names infered from orthology : P21580 / TNF alpha induced protein 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: A3
Gene start: 19000910
Gene end: 19015657
  
Corresponding Affymetrix probe sets: 10368144 (MoGene1.0st)   1433699_at (Mouse Genome 430 2.0 Array)   1450829_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116318
Ensembl peptide - ENSMUSP00000120627
Ensembl peptide - ENSMUSP00000019997
Ensembl peptide - ENSMUSP00000101167
NCBI entrez gene - 21929     See in Manteia.
MGI - MGI:1196377
RefSeq - NM_009397
RefSeq - XM_006512702
RefSeq - NM_001166402
RefSeq Peptide - NP_001159874
RefSeq Peptide - NP_033423
swissprot - D3YXE1
swissprot - Q60769
swissprot - D3Z5R6
Ensembl - ENSMUSG00000019850
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnfaip3ENSDARG00000027777Danio rerio
 TNFAIP3ENSGALG00000013861Gallus gallus
 P21580ENSG00000118503Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otud7a / Q8R554 / OTU domain-containing protein 7A / Q8TE49* / OTU deubiquitinase 7A*ENSMUSG0000003351024
B2RUR8 / Otud7b / OTU domain-containing protein 7B / Q6GQQ9* / OTU deubiquitinase 7B*ENSMUSG0000003849523
Q7M760 / Zranb1 / zinc finger, RAN-binding domain containing 1 / Q9UGI0* / zinc finger RANBP2-type containing 1*ENSMUSG0000003096714


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain
 IPR033478  A20 peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001922 B-1 B cell homeostasis IMP
 biological_processGO:0002237 response to molecule of bacterial origin IDA
 biological_processGO:0002315 marginal zone B cell differentiation NAS
 biological_processGO:0002632 negative regulation of granuloma formation NAS
 biological_processGO:0002634 regulation of germinal center formation IMP
 biological_processGO:0002637 regulation of immunoglobulin production IC
 biological_processGO:0002677 negative regulation of chronic inflammatory response IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009611 response to wounding NAS
 biological_processGO:0010507 negative regulation of autophagy NAS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination ISO
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0032495 response to muramyl dipeptide IMP
 biological_processGO:0032691 negative regulation of interleukin-1 beta production IMP
 biological_processGO:0032703 negative regulation of interleukin-2 production ISO
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0034115 negative regulation of heterotypic cell-cell adhesion NAS
 biological_processGO:0034140 negative regulation of toll-like receptor 3 signaling pathway ISO
 biological_processGO:0034148 negative regulation of toll-like receptor 5 signaling pathway IDA
 biological_processGO:0035871 protein K11-linked deubiquitination IBA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045088 regulation of innate immune response IC
 biological_processGO:0045732 positive regulation of protein catabolic process ISS
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0048662 negative regulation of smooth muscle cell proliferation ISS
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:0050869 negative regulation of B cell activation IDA
 biological_processGO:0060548 negative regulation of cell death IMP
 biological_processGO:0070301 cellular response to hydrogen peroxide IMP
 biological_processGO:0070429 negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
 biological_processGO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
 biological_processGO:0070536 protein K63-linked deubiquitination ISO
 biological_processGO:0070936 protein K48-linked ubiquitination ISS
 biological_processGO:0071108 protein K48-linked deubiquitination IBA
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0072573 tolerance induction to lipopolysaccharide ISO
 biological_processGO:0072666 establishment of protein localization to vacuole IDA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors NAS
 biological_processGO:1903364 positive regulation of cellular protein catabolic process IDA
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IDA
 biological_processGO:2000349 negative regulation of CD40 signaling pathway ISO
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0002020 protease binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019900 kinase binding IDA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043130 ubiquitin binding ISO
 molecular_functionGO:0043621 protein self-association ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061578 Lys63-specific deubiquitinase activity ISO
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Smn1tm2Cdid/Smn1tm2Cdid
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

Allelic Composition: Tnfaip3tm1.1Gho/Tnfaip3tm1.1Gho
Genetic Background: involves: C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001245 thick dermal layer "increased depth of the dermis" [J:65033]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tcirg1tm1Utku/Tcirg1tm1Utku
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003293 rectal hemorrhage "bleeding in the rectum" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1atm1Imx
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama,Tnfrsf1atm1Imx/Tnfrsf1a+
Genetic Background: involves: C57BL/6J

Allelic Composition: Tnftm1Gkl/Tnftm1Gkl,Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008164 abnormal B-1a B cell morphology "any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008168 decreased B-1a cell number "reduced number of the B-1 B cell subset bearing the CD5 surface marker" [CL:0000820, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008170 decreased B-1b cell number "reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell" [CL:0000821, PMID:11861604]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008173 increased follicular B cell number "greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mir451atm1.2Doca/Mir451atm1.2Doca
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * BALB/cJ

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0008783 decreased B cell apoptosis "reduction in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm2Ama/Tnfaip3tm2Ama,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm2Ama/Tnfaip3+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myd88tm1Aki/Myd88tm1Aki,Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

 MP:0009246 pale spleen "spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009338 increased splenocyte number "increase in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfaip3tm1.1Awai/Tnfaip3tm1.1Awai
Genetic Background: involves: 129P2/OlaHsd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

 MP:0010210 abnormal circulating cytokine level "deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm1Homy/Tnfaip3tm1Homy,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfaip3tm3.1Ama/Tnfaip3tm3.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm3.1Ama

Allelic Composition: Tnfaip3tm4.1Ama/Tnfaip3tm4.1Ama
Genetic Background: C57BL/6J-Tnfaip3tm4.1Ama

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic Background: Not Specified

 MP:0013415 increased myeloid cell number in bone marrow "increase in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow" [IMPC:Saran]
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Allelic Composition: Tnfaip3tm1.1Gho/Tnfaip3tm1.1Gho
Genetic Background: involves: C57BL/6J

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
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Allelic Composition: Tnfaip3tm1.1Gho/Tnfaip3tm1.1Gho
Genetic Background: involves: C57BL/6J

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
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Allelic Composition: Tnfaip3tm1.1Gvl/Tnfaip3tm1.1Gvl,Tg(Vil1-cre)997Gum/0
Genetic Background: B6.Cg-Tnfaip3tm1.1Gvl Tg(Vil1-cre)997Gum

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex
 ENSMUSG00000020400 Tnip1 / Q9WUU8 / TNFAIP3 interacting protein 1 / Q15025*  / reaction / complex
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / reaction
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / complex / reaction
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / reaction
 ENSMUSG00000004535 Q3UKC1 / Tax1bp1 / Tax1-binding / Q86VP1* / Tax1 binding protein 1*  / complex
 ENSMUSG00000055994 Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*  / reaction
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / complex / reaction
 ENSMUSG00000021408 Ripk1 / Q60855 / Receptor-interacting serine/threonine-protein kinase 1 / Q13546* / receptor interacting serine/threonine kinase 1*  / complex
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / reaction
 ENSMUSG00000059866 Tnip2 / Q99JG7 / TNFAIP3 interacting protein 2 / Q8NFZ5*  / complex / reaction
 ENSMUSG00000044162 Tnip3 / TNFAIP3 interacting protein 3 / Q96KP6*  / complex / reaction






 

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