ENSMUSG00000038058


Mus musculus

Features
Gene ID: ENSMUSG00000038058
  
Biological name :Nod1
  
Synonyms : Nod1 / Nucleotide-binding oligomerization domain-containing protein 1 / Q8BHB0
  
Possible biological names infered from orthology : nucleotide binding oligomerization domain containing 1 / Q9Y239
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: B3
Gene start: 54923949
Gene end: 54972612
  
Corresponding Affymetrix probe sets: 10544891 (MoGene1.0st)   1454733_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145005
Ensembl peptide - ENSMUSP00000145123
Ensembl peptide - ENSMUSP00000055747
Ensembl peptide - ENSMUSP00000130487
NCBI entrez gene - 107607     See in Manteia.
MGI - MGI:1341839
RefSeq - NM_172729
RefSeq - XM_006505278
RefSeq - NM_001171007
RefSeq Peptide - NP_001164478
RefSeq Peptide - NP_766317
swissprot - A0A0N4SV93
swissprot - Q540J8
swissprot - Q8BHB0
swissprot - A0A0N4SVI7
Ensembl - ENSMUSG00000038058
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nod1ENSDARG00000036308Danio rerio
 NOD1ENSGALG00000036807Gallus gallus
 NOD1ENSG00000106100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*ENSMUSG0000005599432
Nlrc3 / Q5DU56 / Protein NLRC3 / Q7RTR2* / NLR family CARD domain containing 3*ENSMUSG0000004987121
Nlrc5 / C3VPR6 / Protein NLRC5 / Q86WI3* / NLR family CARD domain containing 5*ENSMUSG0000007415121
Ciita / P79621 / MHC class II transactivator / P33076* / class II major histocompatibility complex transactivator*ENSMUSG0000002250417
Nlrx1 / Q3TL44 / NLR family member X1 / Q86UT6*ENSMUSG0000003210915


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006952 defense response RCA
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016045 detection of bacterium IEA
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IMP
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042228 interleukin-8 biosynthetic process ISO
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071225 cellular response to muramyl dipeptide IEA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IEA
 biological_processGO:1904417 positive regulation of xenophagy IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0050700 CARD domain binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nek1kat-2J/Nek1kat-2J
Genetic Background: C57BL/6J-Nek1kat-2J/J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nod1tm1Inoh/Nod1tm1Inoh,Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nod1tm1Inoh/Nod1tm1Inoh,Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nod1tm1Inoh/Nod1tm1Inoh,Nod2tm1Flv/Nod2tm1Flv
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / reaction
 ENSMUSG00000022414 Tab1 / Q8CF89 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 / Q15750* / TGF-beta activated kinase 1 (MAP3K7) binding protein 1*  / complex / reaction
 ENSMUSG00000036712 Cyld / Q80TQ2 / Ubiquitin carboxyl-terminal hydrolase CYLD / Q9NQC7* / CYLD lysine 63 deubiquitinase*  / reaction
 ENSMUSG00000028284 Map3k7 / Q62073 / Mitogen-activated protein kinase kinase kinase 7 / O43318*  / complex / reaction
 ENSMUSG00000035476 Tab3 / Q571K4 / TGF-beta activated kinase 1/MAP3K7 binding protein 3 / Q8N5C8* / TGF-beta activated kinase 1 and MAP3K7 binding protein 3*  / complex / reaction
 ENSMUSG00000041135 Ripk2 / P58801 / receptor (TNFRSF)-interacting serine-threonine kinase 2 / O43353* / receptor interacting serine/threonine kinase 2*  / reaction / complex
 ENSMUSG00000015755 Tab2 / Q99K90 / TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 / Q9NYJ8* / TGF-beta activated kinase 1/MAP3K7 binding protein 2*  / complex / reaction
 ENSMUSG00000026029 Casp8 / O89110 / Caspase-8 Caspase-8 subunit p18 Caspase-8 subunit p10 / Q14790* / caspase 8*  / complex / reaction
 ENSMUSG00000038058 Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*  / reaction / complex






 

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